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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

UFS hosts Nobel Laureate

2010-01-15

The University of the Free State (UFS) will host the 1991 Nobel Laureate in Chemistry, Prof. Richard Ernst from Switzerland, on its Main Campus in Bloemfontein from 22-26 January 2010.

Prof. Ernst’s visit to the UFS is part of an extended tour of South African higher education institutions and the National Research Foundation. His visit will coincide with the fourth presentation of the Cheese fondue that had previously been presented with great success in Europe.

The Cheese fondue concept is the brainchild of Prof. Hartmut Frank of the University of Bayreuth in Germany, who is currently a visiting fellow at the UFS Department of Chemistry.

This concept posits that technical advances alone are insufficient for an agreement to be reached on the minimum respect between the various groups and individuals within a society. It proposes that for this to be achieved there has to be a concurrent development of empathy and emotional synergy. In other words, there has to be spiritual acceptance and tolerance of the different cultural or religious ways of coming to terms with the deep-seated need for a spiritual home.

To this effect the UFS will host a Braai Workshop on Saturday, 23 January 2010 to promote this understanding, hence this year’s theme Justice, a matter of respect, ethics and empathy. The invitation to the workshop is open to the public and those who are interested should confirm their attendance with Ms Stefanie Naborn on 051 401 2531 before Monday, 18 January.

Prof. Ernst will present a paper on Justice – the Culture of Responsibility; Prof. Patrizio Bianchi, the Rector of the University of Ferrara in Italy, will focus on the topic After the Global Crisis: Justice and Wellbeing – the Goals of Economy; while Judge of Appeal, Fritz Brand will talk about Justice – the South African reality.

Prof. Ernst, Prof. Bianchi and Judge Brand will also take part in a panel discussion, together with the Rector and Vice-Chancellor of the UFS Prof. Jonathan Jansen and Prof. Johan Henning, Dean of the UFS Faculty of Law.

Subsequent to that, Prof. Bianchi will present a lecture on the topic Globalisation, Agriculture and Industrial Development in the CR Swart Auditorium on the Main Campus on Monday, 25 January 2010 from 10h00 - 12h00. Prof. Ernst's lecture is from 12h30 - 14h30.

For more information, contact Ms Stefanie Naborn on 051 401 2531 or at nabornsa@ufs.ac.za or Prof. Aldo Stroebel on 051 401 3506/3403 or at stroebea@ufs.ac.za .

Media Release
Issued by: Mangaliso Radebe
Assistant Director: Media Liaison
Tel: 051 401 2828
Cell: 078 460 3320
E-mail: radebemt@ufs.ac.za
15 January 2010

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