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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

US ambassador impressed by the UFS class of 2010

2010-01-19

Mr Donald Gips

“Students should learn to look beyond themselves to break up the barriers that keep them apart as human beings.”

This was the message of the USA ambassador to South Africa, Mr Donald Gips (pictured), to the first-year students who had enrolled at the university for the first time, during the grand opening of the Get Success@UFS Week at the University of the Free State (UFS) in Bloemfontein.

“Take the advantage of the opportunities you have here to grow outside yourselves, to prove the value of diversity and make this university a place where you will grow as an individual; and also contribute back to the community,” he said.

He said the UFS was a beautiful campus undertaking an incredible mission to change the face of South Africa.

“It is incredible and exciting to listen to the energy and to see the enthusiasm of all the students here to make this one of the best universities in the country and setting an example to the world,” he said.

On transformation at higher education institutions, Ambassador Gips said that, just like in the USA, transformation was incredibly difficult.

“It is an ongoing project that everyone has to keep working towards,” he said. “But I am quite convinced that being here today and watching the students and professors tackle this challenge, this university will succeed.”

Addressing the new students, the Rector and Vice-Chancellor of the UFS, Prof. Jonathan Jansen, quoted from one of the famous speeches by the great Martin Luther King Jr. and asked the question: “What is or can be the content of your character?”

He implored the students to judge fellow students by the content of their character and not by the colour of their skins.
“If we succeed with you, our country will succeed. If we succeed with you, our university will succeed,” he said

Prof. Jansen said it was the first time in the history of the UFS that students were integrated as human beings.

“This is the most integrated group of students the UFS has ever had,” he said.
He appealed to them to live their dreams, learn to embrace others, study seriously, make a difference; and guide their leaders.

The purpose of the Get Success@UFS Week is to acquaint the first-year students with the UFS and the academic opportunities that are available to them. The aim is to:
help students succeed academically;
help students to adjust to and get involved in the university environment;
assist parents and other family members in understanding the complexity, demands and services in the University environment; and
provide an opportunity to learn more about incoming students through formal and informal means.

Media Release
Issued by: Mangaliso Radebe
Assistant Director: Media Liaison
Tel: 051 401 2828
Cell: 078 460 3320
E-mail: radebemt@ufs.ac.za
19 January 2010

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