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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

UFS apologises for noise disturbance during newcomers' student festival

2010-02-01

Last night (Saturday, 30 January 2010), the University of the Free State (UFS) received various complaints regarding disturbance caused by the noise during a student function that took place at the Rag Farm on the Main Campus.

"I wish to apologise on behalf of the UFS for the inconvenience that residents in the neighbouring residential areas had to suffer during the Newcomers’ Student Festival last night,” said Mr Rudi Buys, Dean of Student Affairs at the UFS.

The function took place to conclude the welcoming period for new students. “Although strict measures applied regarding the staging of the event, amongst others, cut-off times for the performances of the guest artists and die organisation of the Rag Farm to prevent excessive noise, various unexpected factors made this difficult,” said Mr Buys.

One of the factors was the fact the more than double the expected number of spectators attended the event. As a result of this, measures pertaining to crowd control had to be adjusted. “Although we managed to end the event without any incidents, I am truly sorry that we could not bring the disturbance caused to the neighbouring suburbs to an end earlier,” he said.

“We are committed to finding a sustainable solution to those types of challenges that student events at the Rag Farm can offer to the neighbouring residential areas. Therefore we are going to call meetings with residents and community leaders of the residential areas in order to resolve the problems in a collaborative manner,” Mr Buys said.

An internal evaluation of the situation shall also be undertaken in order to rectify any possible errors or shortcomings in the organisation of the Newcomers’ Student Festival, as well as regarding the organisation of future student events.

“We would like to thank residents of the neighbouring residential areas for the exceptional way in which they often exercise patience, show understanding and make allowances for the times when student activities taking place on the Main Campus become demanding. It is therefore important for us to find solutions to challenges in this regard and engage in meaningful cooperation with residents,” said Mr Buys.

Media Release
Issued by: Lacea Loader
Director: Strategic Communication (actg)
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl@ufs.ac.za
31 January 2010

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