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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

UFS Rector spreads the Kovsie spirit

2010-02-12

Prof. Jonathan Jansen (middle) and UFS students Willien du Preez (far left) and Mbulelo Mpofana (far right) together with learners they met while on their tour of Eastern Cape schools.
Photo: Supplied

Prof. Jonathan Jansen, Rector and Vice-Chancellor of the University of the Free State (UFS), recently joined the Faculty of Economic and Management Sciences on a tour of schools in the Eastern Cape Province. Prof. Jansen sees the tour as a staggering success: “It was hard work, but a lot of fun. I can’t wait to visit other provinces and spread the true Kovsie spirit throughout South Africa.”

The tour kicked off at Aliwal North, where 36 students, parents and teachers from schools in Aliwal North were addressed.

In Queenstown they were awaited by more than a hundred people. Hoërskool Hangklip, Queen’s College Boys High, Girls High and Maria Louw Secondary School attended the function.

The evening function was hosted by Hudson Park High School. Representatives from many schools, including George Randell High School, Stirling High School and Claredon Girls High School made up the 174 people in attendance. The next morning motivational speeches were delivered at Grens Hoërskool and Stirling High School. George Randall High School also requested a visit from Prof. Jansen during the previous evening’s function.

The final function was held at Grey High School in Port Elizabeth. Hundred-and-thirty-four people from the top schools in Port Elizabeth attended the function. These included Victoria Park High School, Theodor Herzl School, Hoërskool Andrew Rabie, Alexander Road High School, Ethembeni Enrichment Centre and Nico Malan in Humansdorp.

Sadly, the tour had to end, but at least it ended on a high note. Ethembeni Enrichment Centre and Chapman’s High School were the last schools on the itinerary, but certainly not the least. The schools might not have all the resources at their disposal, but their enthusiasm and unquenchable spirit and pride were incredible.

Willien du Preez and Mbulelo Nkululeko, two students who accompanied the tour, were awed at the experience: “It was not only a privilege, but also proof that the university strives to give students wonderful learning opportunities. It also confirms our Rector’s stand: the university is not just offering students a degree, but also the opportunity to grow as humans. And that is what adds real value to our lives.”

According to Prof. Tienie Crous, Dean: Economic and Management Sciences, the tour achieved its goals, and much more: “We redeemed our university in other provinces while marketing it at the same time.”

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