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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Final lecture in Darwin series presented at the UFS

2010-02-23

At the lecture were, from the left: Prof. Terence McCarthy, Prof. Jo van As, Chairperson of the Darwin 200 Committee and Head of the Department of Zoology and Entomology at the UFS, Prof. Bruce Rubidge, Elsabe Brits, journalist at Die Burger and Esther van der Westhuizen, presenter on Groen.
Photo: Leonie Bolleurs

The University of the Free State (UFS), in collaboration with the Central University of Technology, Free State (CUT) and The National Museum in Bloemfontein recently hosted the final lecture on the Charles Darwin lecture series entitled “The story of life and survival”.

The lecture was presented by Prof. Bruce Rubidge, the Director of the Bernard Price Institute for Paleontological Research at Wits University and Prof. Terence McCarthy, a Professor of Mineral Geochemistry at Wits and Head of the Department of Geology. Proff. Rubidge and McCarthy are co-authors of the book The Story of Life on Earth.

Their lecture with the topic “Trends in evolution and their bearing on the future of humankind” dealt with the future of evolution. According to Prof. Rubidge, ninety-nine percent of the species that have ever lived are extinct. “We are living in a time of mass extinction. Fifty thousand species become extinct annually,” he said.

Prof. McCarthy discussed many factors that can result in mankind’s extinction today. The impact of climate change, big volcanic eruptions, a comet or asteroid hitting earth, tsunamis and the collapsing of sea islands are some of the factors Prof. McCarthy believes could cause great catastrophe’s on earth.

“We live on the brink of this all the time,” he said.

Prof. McCarthy also believes that we can avoid these catastrophes. By allowing only one child per family we can shrink the global population with 30% per generation. This is doable in a short time span,” he said.

Other ideas he had on saving mankind from getting extinct is to create extensive ecological reserves on land but especially in the ocean, to decentralise everything, to change to renewable energy, to recycle resources and to be vigilant in doing this.

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