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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Students excel in legal interpreting programme
2010-02-24

Prof. Ezekiel Moraka, Vice-Rector: External Relations at the UFS with one of the students who received a diploma.
Photo: Mangaliso Radebe


A success rate of 90% was achieved by the first group of 100 students that successfully completed the two-year Diploma in Legal Interpreting at the University of the Free State (UFS).

The group recently received their diplomas at the ceremony held on the Main Campus in Bloemfontein.

The programme, offered by the university’s Department of Afroasiatic Studies, Sign Language and Language Practice, in collaboration with the Department of Justice and Constitutional Development and Safety and Security Sector Education and Training Authority (SASSETA), is the only one of its kind in South Africa.

“The numbers that we are talking about here, if one looks at the needs of the country as such, is a small fraction,” said Advocate Simon Jiyane, Deputy Director General: Court Services in the Department of Justice.

“This is our first programme in collaboration with the UFS and I am hopeful it will lay a very solid foundation for other such programmes to follow.”

The diplomas were conferred by Prof. Ezekiel Moraka, Vice-Rector: External Relations at the UFS, on behalf of the Rector and Vice-Chancellor, Prof. Jonathan Jansen.

He urged the students to use their skills as qualified court interpreters in the context of the challenges that face South Africa such as HIV/Aids, racism, transformation, unemployment, poverty, job losses, and many other such challenges.

“This is the reality we are faced with, all of us,” he said. “It requires skilful and morally upright people to address it adequately and effectively. You are adding up to the number of skilful people in our country and that means you have a critical role to play.”

He said the UFS, as a societal structure, is equally affected by those challenges because of being accountable to and economically dependent on society.

He also urged the students to use their skills to make contributions to the processes of transformation that are underway at the UFS.

“For instance, the UFS as a national asset has to transform to that level of being a true national asset. We need your full participation in this process so that we can together ensure the relevance of this university as a true South African university,” he said.

Advocate Jiyane urged universities to also look at some of the initiatives that the government takes to improve service delivery. One such initiative is a pilot project focusing on the use of indigenous languages in courts.

“Its aim is to ensure that our courts begin to recognise all official languages in terms of conducting their business,” he said.

“It is our responsibility as a department that, through this project, we begin to build those languages so that they are on a par with the other languages that are being utilised in our courts.”

The department has permanently employed two of the students who received their diplomas, while one of them, Ms Nombulelo Esta Meki, was awarded a bursary by SASSETA to study for a BA in Legal Interpreting. Ms Meki was the top achiever of the programme with an average of 86%.

Media Release:
Mangaliso Radebe
Assistant Director: Media Liaison
Tel: 051 401 2828
Cell: 078 460 3320
E-mail: radebemt@ufs.ac.za  
3 March 2010

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