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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Patricia de Lille: “Know the difference between right and wrong.”

2010-03-04

From the left are: Jeanie Britz, MBA student; Garth Botha, MBA student; Ms De Lille; Prof. Tienie Crous, Dean: Faculty of Economic and Management Sciences at the UFS; and Prof. Helena van Zyl, Director: School of Management at the UFS.
Photo: Stephen Collett

Ms Patricia de Lille, the Leader of the Independent Democrats, recently paid a visit to the School of Management at the University of the Free State (UFS). She spoke to students in the MBA programme about the leadership challenges South African business leaders are facing.

Ms De Lille voiced her opinion on many current issues, such as corruption. “Business is standing back with its arms folded and leaving everything to government. In fact, business is doing something very similar to what it was doing during apartheid,” she said.

She added that a business leader and his or her business could be found behind every corrupt transaction. “It is a relationship involving more than one party. If someone accepts a bribe, someone else is paying a bribe,” she said.

Ms De Lille lashed out at business leaders who received extravagant salaries and bonuses even after they had been asked to leave the company. “South Africa needs a new generation of business leaders that truly know the difference between right and wrong,” she pointed out. “And it’s wrong to demand the rest of your contract’s money and bonus after you have been fired because you obviously didn’t do your work.”

Ms De Lille also focused on the role that South African business played. Business should engage with the government to identify problems and find solutions to speed up transformation. “We need young entrepreneurs that are patriotic and think out of the box,” she said.

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