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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Department of Architecture builds next generation of architects

2010-03-22

With Prof. Jonathan Jansen, Rector and Vice-Chancellor of the UFS are René Malan en Sancha Olivier.

Since 1987 first-year architecture students have been building huts on campus annually as part of an introduction to architectural studies at the Department of Architecture at the University of the Free State (UFS).

According to Martie Bitzer, Senior Lecturer in the Department of Architecture, the students build these full-scale huts in groups of two, with responses to orientation, materials (grass, reads, earth construction – mud bricks), climate and community over a period of approximately three weeks.

On the day that the students completed their huts, Prof. Jonathan Jansen, Rector and Vice-Chancellor of the UFS, visited the small community of 27 huts in the veld behind the Rag Farm. Here he was taken on a walk amongst the huts. He also addressed staff and students of the Department of Architecture

“I can smell excellence and goodness,” was some of Prof. Jansen’s remarks as he walked amongst the huts.

“Top students come to our Department of Architecture. Quality attracts quality. The recent achievements of this department are proof of this,” he said.

One of Kovsies final-year students, Wim Steenkamp, was named National Corobrik Architecture Student of the Year 2008. This was the second time in the past three years that a student from the UFS Department of Architecture has won this prestigious competition. The department also received unconditional accreditation from the South African Council for the Architecture Profession (SACAP) for all three courses offered, and over the past few years its students have won the Tripod Photography Competition, the National Cement and Concrete Institute Competition for honours students, and the Carl and Emily Fuchs Foundation Student Prestigious Prize.

This once again confirms the prestige the department enjoys in the field of architecture in South Africa. It is also proof of the quality of staff and the programmes offered at the department.

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