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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Kovsies paint Bethlehem red!

2010-03-20


At the matric evening of the Secondary School Witteberg in Bethlehem were, from the left: Lebogang Motaung; Rozelle Venter; Prof. Jonathan Jansen, Rector and Vice-Chancellor of the UFS; Ernest Bezuidenhout; Donald Motaung; and Mr Rudi Buys, Dean of Student Affairs at the UFS. Photo: Lynda Greyling

“The learners of the High School Witteberg are a wonderful example of the quality of students that we can expect as first years here at Kovsies next year,” Prof. Jonathan Jansen, Rector and Vice-Chancellor of the University of the Free State (UFS) said last night during a matric evening attended by 121 Grade 12 learners and their parents in a packed hall at the Secondary School Witteberg in Bethlehem.

Prof. Jansen and his wife Grace, as well as some of his colleagues were guests of honour at the event.

“We want to make a difference in the lives of our students at Kovsies and we want to ensure that our students make a difference in a divided world. This is why I want each Grade 12 learner who is here tonight to come and study at the UFS,” he told the learners and their parents.

“The UFS is going to become the university in the country that is serious about quality. We want to draw the best students. Quality entails hard work. It is about perseverance and your commitment towards your studies. That is the type of students we want.”

“My door is open to our students and they have access to come and talk to me. I also regularly sit at different places on the campus and then invite students to come and talk to me. I want our students to feel at home here.”

“I also want our students to feel free to talk about the use of language at the UFS. We love Afrikaans, English and Sesotho and are not going to fight about language. We are going to develop the use of Afrikaans so that more students can speak it – and this also goes for English and Sesotho.”

Prof. Jansen said that Kovsie students had to be balanced students. “Our students must also excel in sport, art, etc., because the development of students who are properly prepared for the workplace is what we strive for as a tertiary institution. Therefore we are going to establish an office that assists students in their career preparation and will offer students internships so that they can come into contact with leading firms in the commerce and industry sectors.”

“However, we shall also actively enhance our students’ learning experience and therefore we are going to send a group of first-year students overseas in the second semester this year to gain knowledge about issues like integration and collaboration.”

At the occasion Prof. Jansen announced that bursaries to study at the UFS in 2011 would be awarded to the two top Grade 12 learners of the school.

The Secondary School Witteberg had a 100% pass rate in the Grade 12 final examinations the past few years. In 2009 the school was seventh amongst the top 50 schools in the Free State Province. Five learners from the school were also amongst the top 20 learners in the Province last year. The school has already produced many top students for the UFS.

Mediaverklaring
Issued by: Lacea Loader
Director: Strategic Communication (acting)
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl@ufs.ac.za
18 March 2010

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