Latest News Archive

Please select Category, Year, and then Month to display items

PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

First postgraduate degree in Forensic Genetics in Africa

2010-03-19

At the launch were, from the left, front: Ms Christa Swanepoel (Applied Biosystems), Ms Karen Ehlers (Department of Genetics, UFS), Dr Carolyn Hancock and Ms Vanessa Lynch (both from DNA Project). Middle row: Dr. Sphie Mukwana (Director: Biotech Forensics, Kenya), Mr Pierre Joubert (Director: SAPS Forensic Science Laboratory) and Prof. Johan Spies (Chairperson: Department of Genetics, UFS). Back row: Mr Izak van Niekerk (Southern Cross Biotechnologies) and Mr Loen Ehlers (National Prosecution Authority).
Photo: Stephen Collett

The Department of Genetics at the University of the Free State (UFS) recently launched the first postgraduate degree offered by a tertiary institution in Forensic Genetics in Africa.

“We are at the beginning of something special. The UFS has developed the programme with the aim of providing graduates with the skills and knowledge they would require to work in the field of forensic biology. These graduates will be the first group of professionals that have undergone tertiary training in order to assist in the resolution of crime through forensic science in South Africa. It has also put the UFS in the forefront of training of this nature,” said Prof. Johan Spies, the departmental chairperson.

According to Mr Pierre Joubert, Director at the Forensic Science Laboratory (FSL) in Pretoria, students trained in this programme would easily be employed by the FSL since they would have the appropriate applied and technical training in forensic science.

Currently the FSL has no personnel with degrees in forensic science in its employ. It employs B.Sc. graduates in the fields of microbiology, genetics, molecular biology and biochemistry as forensic analysts. These employees then go through an extensive supplementary training programme for about six months.

Dr Sophie Mukwana, Director of Biotech Forensics in Kenya, said the launch of this programme in South Africa would benefit African countries like Kenya which relied on the USA for this kind of training. She said they hoped to partner with the UFS in this venture.

Applied Biosystems and Southern Cross Biotechnology have donated the necessary equipment to the UFS for this training.

“It is not only important that students should see the equipment but they should also know how to operate it,” said Ms Vanessa Lynch, from the DNA Project.

The DNA Project, in conjunction with the FSL and the UFS, has developed the learning materials which will be presented at the UFS from 2011.

Media Release
Issued by: Mangaliso Radebe
Assistant Director: Media Liaison
Tel: 051 401 2828
Cell: 078 460 3320
E-mail: radebemt@ufs.ac.za

19 March 2010

Back

Economic and Management Sciences

Education

Health Sciences

The Humanities

Law

Natural and Agricultural Sciences

Theology and Religion

Open Distance Learning

Business School

We use cookies to make interactions with our websites and services easy and meaningful. To better understand how they are used, read more about the UFS cookie policy. By continuing to use this site you are giving us your consent to do this.

Accept