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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Faculty of Theology hosts conference on theology and science

2010-03-25

At the conference were, from the left: Prof. Rian Venter, Department of Systematic Theology at the UFS and organiser of the conference; Prof. Isabel Phiri, University of KwaZulu-Natal; Prof. André van Niekerk, Stellenbosch University; Prof. Francois Tolmie, Dean of the Faculty of Theology at the UFS; and Prof. Wentzel van Huyssteen, Princeton, USA.
Photo: Leonie Bolleurs

The Faculty of Theology at the University of the Free State (UFS) presented an interdisciplinary conference with the theme faith, religion and the public university this week.

The conference was preceded by a public lecture: Human Uniqueness? In Search of the Image of God by Prof. Wentzel van Huyssteen of Princeton in the United States of America (USA). In his lecture he asks: What makes humans different from animals? He also discusses the statement: Is there something that science can teach theologians and something that theologians can teach science?

In his lecture Prof. van Huyssteen refers to the prehistoric paintings in, among others, Spain, France and also Mossel Bay in South Africa. According to him these rock paintings shed some interesting light on the nature of humankind. “It seems as if there is a possible religious connotation to these paintings. Among others it becomes clear that man has the ability to ask deeper questions about his existence,” said Prof. van Huyssteen.

This find of prehistoric paintings is also an example of an interdisciplinary search for answers to the question: What makes man different from other species?

The rock art also shows that man sees himself as part of nature. “Being the image of God” has also to do with an awareness of nature and man’s special task therein as image bearer of God,” said Prof. van Huyssteen.

These are interesting perspectives given by other sciences on the nature of man. From the theology the perspective of “man created to the image of God” is added. At this occasion speakers from different disciplines such as law, physics, sociology, philosophy and theology participated in the discussion about the position of religion at a public university.

Other main speakers at this occasion were Prof. Isabel Phiri from the University of KwaZulu-Natal and Prof. Anton van Niekerk from Stellenbosch University.

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