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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

UFS receives exclusive copy of Pasture Science research volume

2010-04-22

From the left are: Dr Malcolm Hensley (Soil, Crop and Climate Sciences, UFS), Prof. Brian Roberts, Ms Cathy Giesekke (UFS Sasol Library) and Prof. Neil Heideman (Acting Dean: Natural and Agricultural Sciences, UFS).
Photo: Lize du Plessis

The University of the Free State (UFS) became the proud recipient of a copy of a Pasture Science research volume.

The 508-page volume was presented by Prof. Brian Roberts, an adjunct professor at the James Cook University in Cairns, Australia, to the UFS Sasol Library. It consists of 43 papers on his agricultural research work in the Free State from 1956 to 1975.

He said the Faculty of Natural and Agricultural Sciences at the UFS had the power and expertise to lead the way in food security in South Africa and in building a sustainable society. He also stated that not enough people were taking food security seriously.

“Whatever else you regard as priority, none is more basic than support for the nation’s food producers,” he said.

The papers in the bound copy are arranged in two groups. The first section focuses on Pasture Management. “This series forms a useful overview of Pasture Science,” he said.

The section on Grassland Science covers all aspects of the maintenance, improvement and utilisation of veld and cultivated grasslands.

The second part is a series of publications arising from his fieldwork in the Free State, Eastern Cape and Lesotho.

“Having read with great interest the curriculum vitae of the Vice-Chancellor of the UFS, I felt a strong inclination to contribute somehow to the transformation process and the emerging future UFS,” said Prof Roberts.

Although he acknowledged that change could not happen overnight he was, however, positive that medium-term results could be achieved in that regard.

“One way of doing this is to focus staff and students’ attention on working towards a sustainable society, an on-going curriculum challenge which should, at an early date, replace the past preoccupation with race – an issue that has dogged progress for too long,” he said.

Prof. Roberts was a foundation lecturer in Pasture Science at the UFS 36 years ago before he left for Australia where he plays a fundamental role in land-use planning.

He is also recognised as the father of Landcare, an Australian partnership between the community, government and business to protect and repair the environment.

Media Release
Issued by: Mangaliso Radebe
Assistant Director: Media Liaison
Tel: 051 401 2828
Cell: 078 460 3320
E-mail: radebemt@ufs.ac.za
21 April 2010

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