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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Kovsies perform well at South African Netball Championships

2010-04-30

Kovsies in the Free State u.19 and u.21 teams who performed excellently at the recent South African Netball Championships. Here are, from the left: Fikile Mkhuzangwe, best defender, Monique Lemon, best centre court, Anja Opperman, best goal shooter and Karla Mostert, overall best player at the South African Netball Championships.
Photo: Gerhard Louw

Karla Mostert, a student at the University of the Free State (UFS), was named as the best player of the tournament at the recent South African Netball Championships that was held in Richards Bay.

At the tournament top players in each position were also identified. The best goal shooter was a Kovsie Anja Opperman. Other Kovsies included the following: Monique Lemon was named as the best centre-court player and Fikile Mkhuzangwe as the best goal keeper.

The Free State’s u.19 and u.21 netball teams that participated in the tournament entirely comprised of Kovsies. Ms Burta de Kock, Assistant Director at the UFS’s KovieSport, is very proud of the Kovsies netball players’ achievements.

Not only did they reach four of the top positions, but they also won each of the ten matches in the round robin, which took them through to the finals. Both teams brought gold home in the finals when Free State u.19 beat Gauteng East 35-25 and Free State u.21 beat North-West South 37-23.

The Kovsies students performed even better when Fikile Mkhuzangwe, Carmen Swanepoel, Ane Botha, Lauren-Lee Christians, Monique Lemon and Nieke Loubser were named amongst the top 20 players in the u.19 age group. In the U/21 age group, four of the 20 top players were Kovsies, namely Anja Opperman, Anja Zandberg, Karla Mostert and Mari-lise Linde.

“Three of our players also qualified as national umpires: Lizahn Zimmerman (Netball SA, C grading), Mari-Lise Linde (Netball SA, C-plus grading) and Johanet Coetzer (Netball SA, C+ grading),” says Ms De Kock.

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