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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

UFS hosts Fulbright senior specialist
2010-06-14

Pictured from the left, are: Prof. Aldo Stroebel (Director: International Affairs), Prof. Daryl Smith, Ms Dineo Gaofhiwe (Manager: International Research Funding Opportunities, UFS) and Mr John Samuel (Interim Director: the Institute for Studies in Race, Reconciliation and Social Justice, UFS).

The University of the Free State (UFS) has, for the past month, hosted Prof. Daryl Smith, Professor of Education and Psychology at Claremont Graduate University in the United States of America (USA), as a senior Fulbright specialist. She was hosted by the Institute for Studies in Race, Reconciliation and Social Justice, under the leadership of Mr John Samuel, who is its Interim Director. She helped in developing and establishing the research agenda of the institute.

A series of policy briefs and research papers will emanate from Prof. Smith’s tenure at the UFS, complemented by work of three additional Fulbright senior specialists who are joining the UFS early in the second semester. Prof. Smith met with various role-players and stakeholders in the domain of social justice, institutional change, transformation and diversity management, and will continue her association with the UFS at both the Institute and the Faculty of Education, in collaboration with its Dean, Prof. Dennis Francis.

Prof. Smith’s current research, teaching, and publications have been in the areas of diversity in higher education, leadership change, organisational implications of diversity, governance, and assessment and evaluation. She earned her Ph.D. in Social Psychology and Higher Education at Claremont Graduate University, her M.A. from Stanford University, and her B.A. in Mathematics from Cornell University.

Amongst many specialist missions, Prof. Smith served as part of two US delegations to the Ford Foundation-sponsored tri-national conferences (India, South Africa, US) on campus diversity in higher education that have taken place in South Africa and the United States. Her most recent book, Diversity’s Promise for Higher Education: Making it Work, is available from Johns Hopkins University Press.

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