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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

An incident-free recess for the UFS
2010-07-19

The improved security measures at the University of the Free State (UFS) have resulted in an incident-free recess on the Main Campus in Bloemfontein during the 2010 FIFA World Cup and the annual Volksblad Arts Festival.

The UFS provided accommodation for international spectators visiting the country for the World Cup and recently also hosted the hugely popular Volksblad Arts Festival without any security glitches.

These successes could be attributed to the hard work of staff members from various divisions at the UFS to ensure that the security was improved.

“The main question we had to deal with was: should our Main Campus be fenced off? This matter had been under discussion for quite some time. In order to ensure the feasibility thereof, a second impact study was done by a consulting engineer,” said Prof. Niel Viljoen, Vice-Rector: Operations at the UFS.

“This study has shown that, given the nature of activities on the campus and the access configuration, it would be difficult, if not impossible, to effectively control access to the campus, especially as far as visitors were concerned. Any type of access control measure would result in delays at the gates, which could have a major impact on the traffic flow, delays, costs and emissions.”

“It is important that our staff and students feel safe on the Main Campus, whether they are walking on campus or working in their offices. In that way we can ensure an environment that is conducive to staff and students to work and study,” he said.

Various measures are being implemented to make the campuses safer. These include, among others:

  • The installation of alarms in buildings on the Main Campus. The project for the South Campus has been completed and the installation of a new alarm system on the Qwaqwa Campus will start soon.

     
  • Staff and students will be required to wear identification cards once the new identification system has been put in place. These cards will allow access to all buildings.

     
  • Fences around the Main Campus are being repaired and the areas around these fences are being cleaned. This project should be completed by August 2010.

     
  • Lights will be installed in badly lit areas on the Main Campus. The first phase of this project includes the area between the Mooimeisiesfontein, Welwitschia and Vergeet-my-nie residences. This project will also be completed by August 2010.

     
  • The walkways on the Main Campus will be patrolled more frequently and effectively.

     
  • Contracted security workers will be utilised more effectively.

     
  • The monitoring of security cameras on the Main Campus on a 24/7 basis. “For this purpose the security room of our Protection Services is in the process of being upgraded,” said Prof. Viljoen.

The possibility of placing security cameras and panic buttons in parking areas and walkways is investigated.

Media Release
Issued by: Mangaliso Radebe
Assistant Director: Media Liaison
Tel: 051 401 2828
Cell: 078 460 3320
E-mail: radebemt@ufs.ac.za  
16 July 2010

 

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