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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Different religions introduced at UFS forum
2010-08-18

 
Mr Ronnie Rosen, leader of the Jewish community in Bloemfontein.

The Inter-Religious Forum (IRF) of the Faculty of Theology at the University of the Free State (UFS) has started a discussion series which offer the opportunity to different religions to introduce themselves. According to Rev. Maniraj Sukdaven from the Department of Religion Studies at the UFS, the purpose of the discourse series is to get to know more about one another’s religion within an atmosphere of respect.

During the last IRF meeting, Mr Ronnie Rosen, leader of the Jewish community in Bloemfontein, gave a talk about the Jewish religion. According to him there is a wide range of Jewish people.

“The one thing, however, that all Jewish people have in common is the Torah or Law-Book. There are 613 instructions that help a Jewish person to organise his life according to the Jewish way of life. For example, a Jewish person who wants to obey the Torah would not consume dairy products and protein together. This life style is not only regarded as a religion, but a way of life, which constantly makes a person aware of his relationship with God,” he explained.

Another interesting fact that transpired during the discussion was that, for the first time in the history of the world, there are more Jews in Israel than in other concentrated areas across the world. Five (5) million Jews are currently living in Israel, while the remaining 10 million Jews are spread across the world.

During the meeting of the IRF forum, persons from amongst others the Baha’i, Hindu and Christian religions participated in the discussion. Other religions that have already been discussed are Hinduism, Christianity, Islam and Rastafarians.

The IRF will also be involved in the structuring of course material about the different religions and an inter-religious conference will be part of the IRF’s programme in 2011.

The IRF is the only institution of its kind at South African universities.



 

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