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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

UFS hosts first International Congress on Calvin Research in Africa
2010-08-31

Present at the Calvin Research Conference were, from the left: Dr Frank Ewerszumrode (OP), Faculty of Catholic Theology at the University of Mainz in Mainz, Germany; Prof. Dr Herman Selderhuis, President of the International Congress on Calvin Research; Prof. Dolf Britz, Director of the Jonathan Edwards Centre Africa at the UFS; and Ntabanyane Tseuoa, Masters student in the Jonathan Edwards Centre at the UFS.
Photo: Leonie Bolleurs

The first International Congress on Calvin Research in Africa was this week presented on the Main Campus of the University of the Free State (UFS) in Bloemfontein. This was the tenth Calvin Research Conference presented. The conference is presented every four years.

The theme of the congress was: Reconciliation in the Theology of Calvin. Presentations were made about, amongst others, Calvin’s viewpoint regarding slavery and social justice. There was also a discussion about the extraordinary interest to record the original Calvin texts in databases and to make it available to researchers worldwide.

According to Prof. Dolf Britz, Director of the Jonathan Edwards Centre at the UFS, the objective of the congress was to study original Calvin sources critically. “An important part of the congress’ work is to publish an important part of Calvin’s work in a comprehensive text critical edition. This process is already well advanced and includes a number of unknown texts,” said Prof. Britz.

With its research on Calvin, the UFS emphasises the study of original theological sources. “This approach makes the Faculty of Theology part of the UFS’s strategy towards internationalisation. This is also one of the reasons why the UFS was selected by Yale University in America as partner in the recent establishment of the Jonathan Edwards Centre Africa,” said Prof. Britz, whose brainchild it was to also include young upcoming researchers with the study of original sources and classical languages such as Latin.

The congress was attended by researchers and academics from across the world. Twenty young, emerging researchers formed part of this group that was invited by the UFS. According to Prof. Britz, these young researchers are the top achievers at their respective universities, such as the North-West University, Stellenbosch University, Mukanyo Theological College in the Pretoria area and the UFS.

At this event, attended by more than 70 world-renowned Calvin scholars from countries like, amongst others, Taiwan, Japan, South Korea, Finland, Switzerland, France, The Netherlands, America, Germany and Hungary; UFS academics like Prof. Eric de Boer, Extraordinary Professor in Classical and Reformed Theology and students like Rev. Ntabanyane Tseuoa from Lesotho, read and presented papers as well.

According to Prof. Britz this congress was a very good opportunity to introduce the UFS to the rest of the world.

Media Release
Issued by: Mangaliso Radebe
Assistant Director: Media Liaison
Tel: 051 401 2828
Cell: 078 460 3320
E-mail: radebemt@ufs.ac.za  
31 August 2010
 

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