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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Prof. Jansen is a "charmer", say students
2010-09-14

Prof. Jansen with Transport personnel.
Prof. Jansen with a B.Ed. student, Nokubonga Mdlalose.
Prof Jansen with Mr Samuel Mensah.
Prof Jansen with Sibusiso Macu, Sindiswa Masango, Mbali Phakathi and Masebabatso Mofokeng.
Prof. Jansen with Ms Mtombeni (in a white coat )

CHARMING, DOWN TO EARTH, STREEWISE … these are some of the words staff and students on the Qwaqwa Campus used to describe our Rector and Vice-Chancellor, Prof. Jonathan Jansen during his recent courtesy visit to the campus.

Prof. Jansen easily mingled and joined in conversations like a person who was acquainted to the groups of friends that he spoke to. Topics ranged from “girlfriends and boyfriends, how easy or difficult that course was, this and that party”, and of course serious academic talk.

“Prof. Jansen jokingly asked me about my white coat and whether I was a medical doctor. And when I answered that I am a cleaners’ supervisor, he became more interested in what I had to tell him,’ said Ms Dineo Mtombeni, a Maintenance Services supervisor.

“He continued to praise me and my colleagues for the cleanliness on campus and I must say he showed that he is a caring person, despite his position,” concluded Ms Mtombeni.

“I was happy to see Prof. Jansen chatting informally with students and staff. I asked him what he thought of our campus and he said he would know it better once he started teaching here once or twice a week,” said Mr Samuel Mensah, Economics lecturer.

“I then invited him to present some Economics classes and he roared with laughter about the difficulty of dealing with our micro and macro aspects of the subject and I asked him to keep it down as that would justify my students’ fear of the subject,” laughed Mr Mensah.

“He is a nice and friendly person,” said a 19-year-old Bachelor of  Commerce student Masebabatso Mofokeng.

“We shared a joke or two with him and it was one of our best experiences here on campus,” added friends, Sindiswa Masango (19) and Mbali Phakathi (19), who are also studying for their Bachelor of Commerce degrees.

A Bachelor of Education student, Nokubonga Mdlalose (20) described Prof. Jansen as a ‘charmer’.

“He is generous with his time, despite the high position that he occupies. He is approachable, friendly, charming, cool, calm and collected,” said Nokubonga.

“He asked me about my studies and I told him I wanted to make a difference in as far as teaching science is concerned. He was very interested in my Biology experiments and I am so glad I met him,” concluded Nokubonga.

– Thabo Kessah

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