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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

UFS presents first Beyers Naudé Memorial lecture
2010-09-16

At the Beyers Naudé   Memorial lecture were, from the left: Prof. Jonathan Jansen, Rector and Vice-Chancellor of the UFS; Rev. Cedric Mayson; and Mr Kgotso Schoeman, Chief Executive Officer of Kagiso Trust.
Photo: Dries Myburg

The seventh Beyers Naudé Memorial lecture was presented for the first time at the University of the Free State (UFS) this week. This lecture that is presented at a different university each year took place on the Main Campus of the UFS in Bloemfontein this year. Rev. Cedrick Mayson presented the lecture with under the theme: Crafting a legacy.

According to Rev. Mayson more deeply rooted forms of suppression came forward after the democratic elections in 1994. Liberation from apartheid was, according to Mason, very superficial. The poor were still severely suppressed at economic, political, cultural, religious and environmental level. “We have to apply Beyers Naudé’s legacy of liberation in these areas,” Rev. Mayson declared.

“The system according to which the rich become wealthier and the poor become poorer must be replaced by a system where everybody can have enough. This is only possible with the insight of the oppressed.

“The government and the opposition are dominated by people who seek advantage for their own gain. Regardless of democratic slogans and some enlightened individuals’ rules against corruption and violence, we lack the political will to engage in the transformation of the whole world for the good of all earthlings,” said Rev. Mayson.

According to him, consumer culture has become a fine-tuned instrument for keeping people incomplete, shallow and dehumanised.

“Religions are self-centred. Leaders from most of the religious groupings criticised apartheid but they never joined the struggle to assist in demolishing apartheid. It appears as if religious institutions are not able to address the causes of poverty because they themselves are too rich and too powerful,” said Rev. Mayson.

He ended with the following words: “What we need is a leap of faith. Beyers knew that. The world is waiting for people to claim their legacy and to accomplish a post-religious secular spirituality of ubuntu.”

Rev. Mayson is a former Head of Religious Affairs of the ANC. He had also been a former staff member of the Christian Institute before it was banned. Furthermore, he was the Editor of Pro Veritate. Before he retired, he had also been involved in the South African Council of Churches and the World Conference for Peace.

The memorial lecture, a collaborative effort of the UFS and Kagiso Trust, endeavours to involve South Africans in dialogue about issues that affect our nation. This year the lecture was presented at the UFS for the first time and it will take place on the Qwaqwa Campus of the UFS next year.

Media Release
Issued by: Mangaliso Radebe
Assistant Director: Media Liaison
Tel: 051 401 2828
Cell: 078 460 3320
E-mail: radebemt@ufs.ac.za  
16 September 2010
 

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