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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

HEDSA discusses better services for students with disabilities
2010-09-30

At the gala dinner were, from the left: Anlia Pretorius, Chairperson of HEDSA and Head of the Disability Unit at the University of the Witwatersrand; Dr Blade Nzimande, Minister of Higher Education and Training; Ms Hetsie Veitch, Head of the Unit for Students with Disabilities at the UFS; and Prof. Niel Viljoen, Vice-Rector: Operations at the UFS.
Photo: Leonie Bolleurs

The first ever General Meeting of the Higher Education Disability Services Association (HEDSA) was held on the Main Campus of the University of the Free State (UFS) in Bloemfontein this week. HEDSA is a newly constituted body that represents the Disability Units from the various universities across the country.

The UFS is a member of HEDSA, which aims to work together to promote equal opportunities for students with disabilities in terms of access, participation and success in Higher Education.

The General Meeting forms part of the launching symposium with the theme: New Beginnings and New Directions. The symposium, attended by 15 higher education institutions in South Africa, served as a platform to explore innovative approaches to assist in improving services for students with disabilities.

Dr Blade Nzimande, Minister of Higher Education and Training, was one of the speakers at the gala dinner of this prestigious event. He said that there is still a lot of work to do to overcome discrimination against students as well as staff members with disabilities at higher education institutions. Minister Nzimande quoted from the Soudien report, a government-commissioned report that brought to light discrimination – especially racism and sexism – still endemic at South African universities. “Victims, in this instance referring to students and staff with disabilities, are denied the opportunity – either through a lack of access to opportunities or due to outright discrimination – to realise their full potential. In the process, the country is robbed of valuable but untapped human resources. Higher education institutions cause incalculable damage to South African society by failing to deal boldly with these issues. Where institutions have indeed taken action, the benefits to individuals, to the different social groups in the country, as well as to the institutions themselves, have been major.”

He stated that he believed that HEDSA as well as the symposium could play a vital role that would assist in this process.

Ms Hetsie Veitch, Head of the Unit for Students with Disabilities at the UFS, was elected as treasurer of this body for the following two years. Johnny Mokoka will represent the UFS in HEDSA’s National Student Organisation for Students with Disabilities that was established during the symposium this week.

Media Release
Issued by: Leonie Bolleurs
Strategic Communication
Tel: 051 401 2707
Sel: 0836455853
Email: bolleursl@ufs.ac.za  
30 September 2010

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