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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Honorary Professor delivers inaugural lecture in the Faculty of Theology
2010-10-27

Prof. Peter Lampe.

Prof. Peter Lampe recently delivered his inaugural lecture as an Honorary Professor in the Department of New Testament in the Faculty of Theology of the University of the Free State (UFS).

The title of Prof. Lampe’s inaugural lecture was Theology and rhetorics: how do "res" and "verba" relate to each other, in which he addressed the fundamental question of the role and importance of words and the issue/content in theology. Can content simply be conveyed in any manner? Also in theology, Martin Luther observed that some theologians’ works contain words (verba) and those of others the content (res). In his inaugural lecture, Prof. Lampe pointed out that our knowledge of God/reality specifically has to be construed through the use of words. Words and terminology therefore have to be selected with circumspection. Res and verba stand in close relation to each other.

Prof. Lampe declared that in the post-modern world, a “competition” exists for the best constructed worldview and theologians could make a significant contribution to the construction of a better reality through better judgement of the words they use. 

Prof. Lampe, currently the Chair of New Testament Theology at the University of Heidelberg in Germany, has a rich and varied history in the field of theology. Having attained degrees in theology, philosophy and archaeology in Gottingen, Rome and Berne, Prof. Lampe has enjoyed an illustrious professional career. After receiving his Ph.D. at the University of Berne and teaching New Testament Studies there, Prof. Lampe held the Chairs of New Testament Studies in Virginia (USA) and History and Archaeology of Early Christians in Kiel (Germany), before being appointed to the post he currently holds.

In 2003 he was awarded the German Ecumenical Preaching Award and in Turkey he was the leader of an expedition that discovered the long-lost Montanist headquarters of Pepouza and Tymion.

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