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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Prestigious Helgaard Steyn Prize to be awarded to UFS composer
2010-11-08

 Hans Huyssen.

The composer Hans Huyssen, affiliated with the Department of Music at the University of the Free State (UFS), is to be the current recipient of the prestigious 2010 Helgaard Steyn Prize, the prize-winning work being Huyssen’s Proteus Variations (2006).Annually this award is administered and presented to a selected composer, painter, author, or sculptor by the Universities of the Free State and the North-West on a rotating basis. The judges for this year’s prize were Prof. Bertha Spies, Research Fellow, North-West University, and Professor Extraordinary, University of Pretoria, and Mr Noel Stockton, Senior Lecturer at the University of the Free State.

Hans Huyssen’s musical activities encompass the diverse poles of early and contemporary Western and African music, often in an attempt to assimilate the essential qualities from all these fields. His intense focus on contextuality suggests that he approaches music as a profoundly social force which has a particular role to play in our ‘new’ diversified South African society.

The Proteus Variations were commissioned by the Deutsche Welle Radio for the South African National Youth Orchestra 2006, and were premiered at the Beethoven Bonn Festival during 2006. These variations are described by the composer as “a musical representation of South Africa’s manifold Proteaceae”, named for the Greek god Proteus who, at will, was capable of assuming a spectrum of shapes and appearances. As the composer states: “It is worth noticing that a Protea is South Africa’s national flower. What could be more appropriate in providing a key to an opposite perception and understanding of the country’s diverse cultural expressions? In this regard it is my hope that the Proteus Variations may contribute a little to the wide scope of cultural responses necessary to begin to do justice to the extremely rich tapestry of our immediate cultural and natural surroundings”.

The prize of R170 000 will be awarded to Hans Huyssen by a representative of ABSA Trust, who is one of the trustees of the Helgaard Steyn Trust, in Bloemfontein on 8 November 2010.

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