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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

UFS academics work on text book about legal requirements for cultural institutions
2010-11-09

Prof. Johan Henning, Dean of the Faculty of Law, UFS; Prof. Loot Pretorius, also from the Faculty of Law; and Mr Tokkie Pretorius, Director of the War Museum in Bloemfontein.

A team consisting of Prof. Johan Henning, Dean of the Faculty of Law at the University of the Free State (UFS), Prof. Loot Pretorius, also from the Faculty of Law, and Mr Tokkie Pretorius, Director of the War Museum, is going to tackle a project which will focus on the new legal requirements for cultural institutions, with special reference to national museums.

Previously this team has written a textbook on the legal position of development corporations, which is regarded as a standard work about this topic.

Museum managers often come from the expert conservation and research environment and find it difficult to comply with the new legal requirements pertaining to national museums.

National museums, amongst which counts the War Museum of the Boer Republics, are classified by the Public Finance Management Act (PFMA) no. 1 of 1999 as Public Entities.

This Act also states specific accounting requirements regarding the accounting standards, year-end statements and the auditing process on the one hand, but on the other hand specific requirement with regard to corporate management.

The King II Report and it most recent extension, King III, sets specific guidelines to be followed in the managerial process and specifically emphasises the role and responsibilities of non-executive boards of directors (board members) and those of the executive director (chief executive officer). The Cultural Institutions Act, no. 119 of 1998, regulates the operation of national museums, amongst others the constitution and functions of the boards of national museums. Various other forms of legislation also apply to national museums.

According to Prof. Pretorius they aim to publish the book within the next 18 months.
 

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