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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

A mind shift needed in agriculture in Africa
2010-12-02

Prof. Frans Swanepoel (Centre for Sustainable Agriculture and Rural Development), Prof. Monty Jones, Prof. Driekie Hay (Vice-Rector: Teaching and Learning), Prof. Alice Pell (Cornell University, USA), and Prof. Izak Groenewald (Director of the Centre for Sustainable Agriculture and Rural Development) at the inaugural lecture of Prof. Jones as Professor Extraordinary. 
- Photo: Stephen Collett

Food stability is essential for stability in all countries around the world. Radical interventions, and not incremental changes, are necessary to end hunger and poverty in Africa, said Prof. Monty Jones, Professor Extraordinary in the Centre for Sustainable Agriculture and Rural Development at the University of the Free State (UFS), in his inaugural lecture.

Prof. Jones is Executive Director of the Forum for Agricultural Research in Africa (FARA) and Chairperson of the Global Forum on Agricultural Research (GFAR). In his lecture he focused on the contribution of agricultural research to development and food security in Sub- Saharan Africa.

He said Africa is not known for good politics to promote food production. Countries under invest in research, education, knowledge management, agriculture finance, etc. There is also uncertain and restricted access to land. He specially mentioned women’s access.

Sub- Sahara Africa moved from being a net exporter of food to a net importer of food (28%). “Government spending on agriculture and transport went down and stagnated. A mind shift is necessary. Africa has the resources. We must take advantage of the opportunities,” he said, and added: “Africa must create visionary and inspirational leaders and managers who can drive developmental issues.”

Prof. Jones emphasised that fact that nutritional security is just as important as food security. The number of hungry people has grown to more than a billion in 2009. Hunger is the most severe in the developing world, especially Africa. Added to this is Africa’s population growth that i s also higher than the rest of the world. It is estimated that the demand for food in Africa will double in the next 40 years.

“Research and development alone cannot win the war against hunger in Africa. Everyone has a role to play,” he said.
– Leatitia Pienaar.

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