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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

UFS receives an award from the World Universities Forum
2011-01-11

The University of the Free State (UFS) has received the World Universities Forum (WUF) Award for Best Practice in Higher Education during 2010.

The Best Practice Award recognises the most significant practices of the year around the world. The UFS’s implementation of a number of interlocking innovations to transform the institution is recognised with the award.
 
These innovations include:
  • campus-wide racial integration among students;
  • the reinvigoration of the academic culture;
  • the nurturing of the most promising young scholars by means of the Vice-Chancellor's Prestige Young Scholars Programme;
  • sending 71 first-year students to top American universities to assist with their development into non-racial campus leaders;
  • the revision of the undergraduate curriculum to promote a cross-disciplinary approach to key societal problems;
  • raising the entry requirements;
  • the facilitation of open access to campus leadership through sessions with the Vice-Chancellor and Rector, Prof. Jonathan  Jansen – providing opportunities for public discussion between senior leadership, staff and students;
  • the UFS also extended this spirit of dialogue internationally through the inauguration of its International Advisory Council consisting of key thinkers and practitioners;
  • the identification of 20 of the most dysfunctional high schools in the Free State Province and the building of relationships with those schools. This university-school partnership is based on a strict contract of reciprocal commitments to increase the chances of black children attending university. The WUF applauded this as the most innovative step.
 
“We at the UFS are humbled, but encouraged by the recognition of academic excellence and institutional transformation that comes with this prestigious international award,” said Prof. Jansen.
 
The WUF said in a statement that these innovations demonstrate the profound impact higher education practices can have when they are well conceived and implemented.  “We applaud these innovations and the ways in which they promote racial harmony, student success and overall academic vitality,” the statement reads.
 
The Best Practice Award will be announced formally at this year’s World Universities Forum, which will be held at the Hong Kong Institute of Education from 14-16 January 2011. 
 
 A message of appreciation from Prof. Jansen will be read by Prof. Fazal Rizvi, Programme Convenor of the WUF 2011 during the award ceremony.


Media Release
10 January 2011
Issued by: Lacea Loader
Director: Strategic Communication (actg)
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: news@ufs.ac.za

 

 

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