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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

UFS registration process is proceeding well

2011-01-11

Ms Belinda Venter and her daughter, Stacey Venter, second year student in Consumer Sciences, registering online with the help of Donovan Nell, student assistant and currently a third-year student in Computer Sciences at the UFS.
- Photo: Leonie Bolleurs

The university implemented an online registrations process for senior students this year. “We are one of the first universities in the country where students can do the entire registration process online themselves. The advantage of this new turn in the registration process at the university is that students can register from the comfort of their homes or even from any place in the world,” says Prof. Niel Viljoen, Vice-Rector: Operations at the UFS.

Senior students who experienced problems during the registration programme from 1 November 2010 to 4 January 2011, have the opportunity to, within a programme, address these problems as from 5-12 January 2011. During this period UFS staff members will be available to assist students to register electronically.

However, senior students can still register online after 12 January until 28 January 2011.

The registration process of first-time entering first-year students is also proceeding well. Although a large number of applications for late registration have been received, it can be handled without difficulty.

First-year students are welcomed by Prof. Jonathan Jansen, Vice-Chancellor and Rector of the UFS, on Friday, 14 January and Saturday 15 January 2011 at 09:00 in the Callie Human Centre.

From 17- 21 January 2011, first-year students will receive academic advice at the Callie Human Centre, where after they will be referred for self-registration. These processes will take place according to the scheduled timetable, which appears in the Kovsie Guide. The Kovsie Guide was sent to first-year students, and is also available on the UFS webpage (www.ufs.ac.za/register2011).

The registration process for the Qwaqwa Campus is from 17-21 January 2011 for first-time entering first-year students and from 17-28 January 2011 for senior students.

According to personnel at the registration help desk, the following problems are reported the most frequently:

Forgotten or expired passwords: Students are requested to contact 051 401 2442 to report this problem.
Outstanding registration fees, which lead to the specific student’s account being blocked: Students are requested to contact 051 401 2806 for help in this regard.
If information regarding module codes is required, the relevant faculty can be visited for academic advice.

Classes on the Main and Qwaqwa Campuses will start on Monday, 24 January 2011.

Media Release
11 January 2011
Issued by: Lacea Loader
Director: Strategic Communication (actg)
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: news@ufs.ac.za

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