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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

UFS awards honorary doctorate to Archbishop Emeritus Desmond Tutu
2011-01-01

Archbishop Emeritus Desmond Tutu

The University of the Free State (UFS) will reach a milestone in its history today when an honorary degree, the Doctor of Theology, will be conferred on Archbishop Emeritus Desmond Tutu.

At the same event Archbishop Tutu will launch the university’s International Institute for Studies in Race, Reconciliation and Social Justice.
 
The idea of the establishment of such an institute originated after the Reitz incident in 2008. In 2009, during his official inauguration, Prof. Jonathan Jansen, Vice-Chancellor and Rector, embodied this idea when he stated that the university would be an example of a place where reconciliation, forgiveness and social justice would not only be studied, but where it would also be applied in practice. “Students and scholars from across the world will come to the UFS to study the theory and practice about the building of societies across the boundaries of race, as well as religion, gender, disabilities and national origin,” Prof. Jansen said.
 
The institute is a critical intellectual space where engaged scholarship, public discussion, community engagement and contextually relevant teaching are innovatively harnessed towards exploring and finding solutions to the complex and challenging work of social transformation in South Africa,” says Mr John Samuel, Interim Director of the institute. Mr Samuel was the former Chief Executive Officer of the Nelson Mandela Foundation.
 
According to Mr Samuel, the institute seeks to establish itself as a premier international site for research on race, reconciliation and social justice. “We want to link the manifestations of race in higher education, to the related matters of reconciliation and social justice in the South African context against the backdrop of racial and ethnic conflicts elsewhere in the world,” says Mr Samuel.
 
The institute will, amongst others, publish groundbreaking research, organise national and international conferences about reconciliation and social justice, as well as contribute to the establishment of national and international networks that are actively involved in matters relating to race, reconciliation and social justice. Through its research, the institute will endeavour to understand the challenges facing the UFS better, as well as how to address these challenges. For this reason, the concept of the UFS as a “live laboratory” and the use of evidence-based practice remain important for the university.
 
By honouring Dr Tutu, the UFS recognises the contribution that Dr Tutu has made in the field of Theology through his teachings and the books he has written. However, the UFS is not only honouring him as a moral and religious leader who has maintained his integrity as a Christian. “We honour a great son of South Africa who has made a huge contribution to peace, reconciliation and justice in South Africa and in the world,” says Prof. Jansen.
 
The unveiling of the new corporative brand of the UFS will render further lustre to the day.

Media Release
17 January 2011
Issued by: Lacea Loader
Director: Strategic Communication (actg)
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: news@ufs.ac.za

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