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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Thirteen Scholarships for Science and Mathematics learners awarded

2011-02-15

The Thirteen Scholarship winners are seen here with: Back: Mr Cobus van Breda (Project Manager, School for Continuing Education, far left), Prof. Jonathan Jansen (Vice-Chancellor and Rector of the UFS, Second from the right), Prof Dennis Francis (Dean of the Faculty of Education, on the right), Middle: Ms Elizna Prinsloo (School for Continuing Education, left) and Ms. Pearl Nhlane (SANRAL, right).
- Photo: Stephen Collet

Thirteen learners from the University of the Free State (UFS)’s School for Continuing Education (SCE) were successful in their applications for school scholarships at SANRAL (South African National Roads Agency). This represents more than a third of the successful applications countrywide.

The SCE’s ICT Laboratory aims to enable and encourage more learners to enter into science related studies and careers. To achieve this, 180 selected learners from Grade 10, 11 and 12 are exposed to activities at the ICT Laboratory every year. “It is an attempt not only to foster a positive attitude towards Mathematics and Science amongst learners, but also to raise their knowledge and skills levels through e-Education in Science and Mathematics,” says Mr Cobus van Breda, Project Manager of the programme.

As part of the programme, learners have the opportunity to apply for a scholarship at the sponsor, namely SANRAL (South African National Roads Agency). The scholarship not only covers all school and hostel fees for the particular year, but also includes stationary as well as school and sports outfits of the learner.

At a recent information session for successful learners and their parents held at the UFS, Ms Pearl Nhlane of SANRAL congratulated the learners and said that “SANRAL is recognising the hard work of the learners by investing in them”. Prof. Jonathan Jansen, Vice-Chancellor and Rector of the UFS, in turn thanked SANRAL for their initiative and told the learners “that one has to take the gap when one gets the opportunity”, indicating to the learners that the scholarship can be seen as such an opportunity, since it can possibly pave the way to study benefits in future.

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