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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Eminent Chinese musicians perform at Odeion
2011-03-08

Hing fat-Wong

A renowned and well-known award-winning Chinese musician from Hong Kong, Hing fat-Wong, enchanted music lovers of the classical genre, after joining forces with Frankie Feng, Music Director of Free State Orchestra of Chinese Music (FSOCM), live on stage at our university’s Odeion for the first time in 30 years. Wong and Feng lit up the stage, to a full house, with an outstanding orchestral performance at the FSOCM’s first concert for the year, called Ancient Chinese Classical Music. Wong was invited by the FSOCM in January 2011 to play solo pieces on the traditional Chinese instruments, the pipa and guqin.

Wong conducted two works, Shanbei Suite and Variations on Yang Guan. Both were arranged by Feng and are based on Chinese folk songs and ancient melodies, respectively. According to Wong, ancient melodies refer to all music before the 1911 Chinese Revolution. However, Wong stated that Feng’s arrangement gave new life to these melodies, as played by the FSOCM.
 
Wong proved to the audience that his talent goes beyond the conductor's baton, and includes his ability to play instruments such as the pipa and guqin masterfully, by performing several solo pieces using these two traditional Chinese instruments.
 
During his stay in Bloemfontein, Wong was invited by Prof. Nicole Viljoen from our Department of Music to host a successful seminar on the appreciation of Chinese music. Attendees had the opportunity to listen to a lecture by Wong and gain first-hand experience of classic traditional Chinese instruments being played. The FSOCM is a multi-cultural orchestra and looks forward to hosting more high-quality performances with soloists of the calibre of Wong throughout the year.

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