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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

One of the UFS's newest members welcomed at international organisation.
2011-03-13

Photo: Gerda-Marié Viviers
Prof. Hussein Solomon

One of the University of the Free State’s (UFS) newest members of excellence was recently welcomed as a new member at the relatively new, yet influential, internationally renowned Our Humanity in the Balance (OHIB) organisation. Prof. Hussein Solomon, a month old Senior Professor in Political Science at the university, said he has always wanted to have made a difference in people's lives and dreamt of becoming part of an organisation such as the OHIB. Proofing of Solomon's dedication to his roots, he believes his focus must remain with the African continent. ''I would like OHIB to focus on making the secession process in Sudan as peaceful as possible as well as focusing on ending the ongoing conflicts in Somalia, the Ivory Coast and the Democratic Republic of the Congo. These are immediate goals. In the medium term we need to examine the issues of democratic transformation in countries like Swaziland and Zimbabwe.''

As this Kovsie has worked in peace NGOs, advised diplomats and acts as a serving officer in the South African Air Force and an academic, the compilation of the OHIB board consisting of academics, former senior diplomats and military people and peace activists would be nothing new to him. ''My role is essentially to bring these disparate communities together and to focus energies on a common project. At the moment much attention is being focused on current developments in Libya.''

Other accomplishments of this former Tuks lecturer include Visiting Professor at the Global Collaboration Centre at Osaka University in Japan, Visiting Fellow at the London School of Economics and also respective membership on the Security Council of the Gerhson Lehrman Group of Companies, the International Steering Committee of Global Action to Prevent War, and the International Advisory Council of the Toda Institute for Global Peace and Policy Research in Hawaii. Prof. Solomon was selected in 2008 to serve on the Nelson Mandela Chair of African Studies at Jawahrlal Nehru University in New Delhi, India.

His current area of research expertise include conflict and conflict resolution in Africa; South African Foreign Policy; international relations theory; religious fundamentalism and population movements within the developing world. His publications have appeared in several countries around the world including Switzerland, The Russian Federation and Japan.

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