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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

UFS to send a second group of first-year students overseas
2011-03-23

Some of the students who were chosen in 2010

Following the resounding success of the University of the Free State’s (UFS) Student Leadership Development Programme in 2010, the UFS will send a second group of students to the USA in 2011 and also extend the programme by sending students to various universities in Europe and Asia.

This year a total of 150 first-year students will be selected compared to the 71 students that were selected last year. Last year’s group of students spent two weeks, between September and October 2010, at various universities across the United States.
                                         
The programme intends to expose the students to diverse cultures and enable them to learn leadership skills. The goal of the programme is to build a new class of UFS students who become leaders during their years of study and commit to building a non-racial community during and beyond their years at university.
 
Mr Rudi Buys, the UFS Dean of Student Affairs, says: “With the programme we want to develop participants’ thinking and capacity to lead in the contexts of diversity and change and we hope to direct them to programmes leading to change in student life in general upon their return.”
 
The three core purposes of allowing students an opportunity to study abroad are:
  • to introduce South African students to positive models of racial integration and integrated residential life;
  • to share and exchange ideas around issues of race, racism, racial integration and racial reconciliation, with undergraduate students abroad; and
  • to build long-term networking and collaboration between academics and researchers interested in scholarly work on themes of race, reconciliation and social justice.
 
Last year students were selected based on their ability to reflect critically on knowledge of societal issues and successful candidates were put through a preparatory development programme. They were divided into groups and given assignments to complete during the programme. A similar selection process will be undertaken this year.
 
Upon their return, last year’s group of students demonstrated extremely positive outcomes, during an assessment of the project’s goals and achievements. More than 80% of participants agreed that the course met all expectations; the content was meaningful and challenged their existing views. More than 90% felt that the course meaningfully addressed diversity. Among the successes achieved by the programme is the influence of participants in the student community.
 
Many serve as peer mentors for the Gateway First-Year Welcoming and Orientation Programme, while others serve as mentors in well-being and academic peer advisory programmes. Many have also been elected as members of executive committees of student associations and management committees in residences, while some have availed themselves to run for student governance structures throughout 2011 and 2012.
 
The programme proved to be so successful that it was decided to expand the number of students selected for the programme to 150 this year and first-year students are invited to apply. It is envisaged that 90 students will visit American universities, while 60 will visit institutions in Europe and Asia.
 
Last year the students were hosted by, amongst others, Cornell University, the University of New York, Cleveland State University and the University of Massachusetts.
Yale University, Amherst College and other American universities will join these host universities in 2011, in addition to the European and Asian institutions.
 
Those first-year students who wish to apply can find all the information at www.ufs.ac.za 
 

Media Release
23 March 2011
Issued by: Lacea Loader
Director: Strategic Communication
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: news@ufs.ac.za
 

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