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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Examination format at UFS to change
2011-04-22

A new examination format is to be followed from the coming examination in May 2011 at the University of the Free State (UFS). According to this, the additional examination opportunity is to follow on the heels of the main examination.

According to the new format, students who qualify to write examinations will be compelled to write their papers during the first opportunity, and will only be allowed to write an additional examination once their applications for this examination have been approved. Students who qualify for re-assessment and special examinations will automatically be admitted to the additional examination and will therefore be exempt from the application process.
 
According to Dr Saretha Brüssow, Head: Teaching and Learning at the UFS, the Examination Committee requested the investigation of the double examination which applied previously, due to the pressure it caused on the university systems.
 
She said that, besides this release of pressure on systems such as the registration process, the back-to-back semester-based examination system might also lead to a possible improvement of the academic success rate, due to the shorter time span between the first and the second examination opportunities.
 
Students attended classes poorly in the past due to the second examination opportunity, which took place during the following semester after classes had resumed. “In some cases it is specifically the student at risk, who cannot afford to miss classes, who makes use of the second examination opportunity.”
 
Dr. Brüssow said the registration process was also affected by the previous format due to students who wanted to receive their results first before they registered. Other delays which occurred as a result of the second examination opportunity, were the first annual graduation ceremony which took place late in the year, the awarding of bursaries, and the finalisation of residence accommodation. Adding on to this problematic nature is students who occupy residences in the following academic year without a formal application in order to write during the second examination opportunity in January.
 
The new format is applicable to all students, except those in the Faculty of Health. Main and South Campus students can direct enquiries to addexam@ufs.ac.za. Qwaqwa Campus students should email addexam@qwa.ufs.ac.za.  Information on the new examination format is also available on www.ufs.ac.za.
 
 
Media Release
21 April 2011
Issued by: Lacea Loader
Director: Strategic Communication
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: news@ufs.ac.za
 

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