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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Breakfast in aid of hungry students
2011-06-01

Our university again proved that it cares for the welbeing of its students when a sum of money was presented to the No Student Hungry Project during a breakfast function.

The Centre for Health and Wellness at the UFS organised the event, not only to introduce the scheme to staff and individuals and thank those concerned for their contributions, but also to present the project organisers with a donation of R50 000. Mrs Grace Jansen, wife of Prof. Jonathan Jansen, Vice-Chancellor and Rector and Dr Carin Buys, wife of Mr Rudi Buys, Student Dean, started the project this year after a study found that 20% of students at the UFS have to study on an empty stomach and that this often leads to students leaving the UFS prematurely.

Ms Tanja Malherbe, mistress of ceremonies, said that the project is blessed because it developed from the founder members’ love for the students. The project currently provides 6 000 deserving students with a meal per day.

Prof. Jansen said that although the university encourage academic success, the UFS is also ready to show its mettle on a humanitarian level. “We don’t want students to only study together, but also to eat together.” He added that food can promote a feeling of fellowship, gives comfort and is also a symbol for caring. “It is bad to be hungry, no matter what the colour of your skin. Especially when other people have food and you don’t.”He concluded by saying that we are blessed by giving to other people, and by giving, we also receive.

Ms Tarryn Nell, also from the centre, supported him by comparing caring to candlelight. “It drives the darkness away, involves compassion and gives direction. When two people can get things to change, the rest will follow.” She encouraged the audience to share their warmth, time, knowledge and resources with other people.

During the event, a picture summary also referred to two recent projects the centre hosted. The first was a free medical screening test for staff members and the second a temporary remembrance rose garden, representing the five main causes of deaths in the country. These causes are HIV, ischemic heart disease, stroke, tuberculosis and interpersonal violence.

The proceeds from Prof. Jansen’s book “We need to talk,” will be donated to the project. Persons wishing to make a contribution, can make a payment to the following account: ABSA 157085 0071, reference number 146 674 604, account number 0198, branch code 632 005. Deposit slips can be sent to pelserr@ufs.ac.za. 

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