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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

School of Nursing receives a considerable grant
2011-06-01

Our School of Nursing once again became the proud recipient of a grant from the Atlantic Philanthropies, an international organization dedicated to “bringing about lasting changes in the lives of disadvantaged and vulnerable people”.

Atlantic Philanthropies granted millions of rands to South African nursing training institutions via University Based Nursing Education (UNEDSA), which will provide six recipient institutions the opportunity to transform nursing academic programmes in South Africa over a period of four years.

We recently received a R3 100 000 grant for the school to transform nursing scholarship and clinical practice. This is but the latest installment in a total grant of R16 million.

The School of Nursing, under the leadership of Prof. Anita van der Merwe, former Head of the School of Nursing, submitted a proposal to UNEDSA and was selected as one of the six recipients of the award. The school is now at the beginning of the third financial year of the project.

According to Dr Annali Fichardt from the School of Nursing, the school established a unique Virtual Health Teaching and Learning facility for training students in a non-threatening, simulated environment and to prepare nurses to be capable and to function optimally in the dynamic health-care environment. This provides opportunities for experimentation and sharing of integrated teaching and learning in nursing education.

The project helped establish a new unit for continuing professional development and research capacity development to serve practicing nurses and staff members of the School of Nursing. These initiatives will result in a fully transformed and accredited portfolio of programmes at undergraduate, post-basic and postgraduate levels to meet the needs of a range of health-care settings and learners.

The School of Nursing hopes to create an innovative teaching and learning environment that empowers students and professional nurses to become clinically excellent, able to practice independently in both resource-poor and technology-rich areas, and manage such complexities in an innovative way.

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