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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

UFS unveils Women’s Memorial Garden

2011-08-12

The Women’s Memorial Garden, between the Main and Chemistry building, seen from the top.
Photo: Siegwalt Küsel

Our university rewarded the hard work of women at the university by unveiling a Women’s Memorial Garden at our Bloemfontein Campus on National Women’s Day, 9 August 2011. University Staff, students, some members of our Council and other guests gathered at the university for the unveiling of the new memorial garden.

Prof. Driekie Hay, Vice-Rector: Academic, told the somewhat 50 people at the unveiling that it was a historic day for the UFS, as this was a sign of how far the university have come. Prof. Hay told the women at the function to be proud of their achievements. She said the purpose of Women’s Day was to celebrate the historic struggle and sacrifices of all South African women, especially those who fought against racism and sexism.

The Women’s Memorial Garden consists of a botanical garden with more than 80 plant species. In the middle of the garden is a stone statue with a wild fig tree planted within. Prof. Hay told the guests that the tree’s numerous seeds represent unity and is an indication of real understanding, knowledge and faith, characteristics women at our university should pursue to ensure a sustainable and prosperous future for the UFS. The University leadership will now embark on a process to identify and recognise women from the university community who have made significant contributions during its 107 years of existence.

The memorial garden was designed by Habitat Landscape Architects. Mr Siegwalt Küsel, an architect at the firm, said the garden was developed to be a living monument to women. He said they hope that the garden will become an active learning space for visitors.

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