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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Our Abe Bailey scholars are packing for the UK
2011-08-16

 

Nida Jooste and Ryan Lamb
Photo: Earl Coetzee

Academic excellence and strong leadership has become synonymous with our university, as our two Rhodes scholars for 2011, and the recent announcement of our two Abe Bailey scholars from the UFS have shown.

Nida Jooste and Ryan Lamb are two of the proud recipients of Abe Bailey Travel Bursaries and will be heading off to the United Kingdom on 26 August 2011, to visit several universities in England and Scotland. These two were chosen from hundreds of UFS applicants and will join Abe Bailey bursary holders from the rest of the country.

Both students are academic achievers, but also excel in other fields. This is what set them apart from the rest of the applicants for the bursaries.

Ryan (23), a Medical Physics honours student at our Faculty of Health Sciences, received the Senate Medal for the best bachelor’s degree student at the UFS. He was one of a hundred students at the Brightest Young Minds Summit this year and was one of the 2008 delegates to the World Youth Forum, hosted by the International Association for Poetry and Solidarity in Italy.

This young man is the founder of a group called Poets Anonymous, which provides a platform where poets, artists and dancers in Bloemfontein can express themselves.

Nida (21) is a very familiar face on our Bloemfontein Campus, as she served as the Deputy Chairperson of the Interim Student Council for the past year.

This fourth-year LL.B. student says she has known about the Abe Bailey bursary since her first year, but had to wait to apply, since the scholarship is only open to final-year students and junior lecturers. She applied last year, but did not even make it to the short list for candidates.

“I realise now that I was not involved enough then. Luckily I became much more involved in campus activities during the past year and also improved my academic performance greatly,” she says.

Nida and Ryan both hope to use the opportunity to learn new approaches to solving problems. Ryan says he is looking forward to the opportunity to network with other bursary holders and to share experiences with them, before returning to the UFS to implement what he had learned.

Nida says she also hopes to see how universities in First-World Countries operate, in order to apply that knowledge when she returns to the UFS.

 

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