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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

A journey into self-discovery
2011-08-17

Sandy Little

The launch of the film and book Africa meets Africa: Pathways through the Interior at our university was a huge success.

It forms part of the The Africa meets Africa Project that is known for making connections between knowledge systems in pursuit of learning. It integrates amongst others beadwork and weaving with mathematics.

The film takes one through the Free State and some parts of the Northern Cape. The two actors, Mr Lerato Mokhitli and Ms Sandy Little, are both art students at Kovsies. During the trip they reveal some historic events not known to all. Prof. Jonathan Jansen, Vice-Chancellor and Rector, said: “Our history is a lot more complex and interesting than current texts allow. Much of what happened laid the foundations for trauma, and triumph is poorly understood. More so, is the history of the ordinary.”

The film and book are funded by National Heritage Council and FirstRand. It was launched in other provinces, among them KwaZulu-Natal. The Africa meets Africa Project aims to use the book in the Free State and Northern Cape in the Further Education and Training (FET) phase for educators and university students.

Prof. Jansen furthermore said: “I would definitely recommend the book with some additions, such as representation of excluded cultures. This would include white ethnographic histories and cultures and the intersections across black/white, African/European histories. I would also make the subject history compulsory to ensure that children would be exposed to our complex history.”

Ms Moipone Kabaoe, a third-year B.Soc.Sc. student at UFS, said: “The film was very informative and clarified some things. I also believe the actors have actually grown from the experience and they did a great job.”

Mrs Anna Mokhitli was ecstatic at the launch, as any proud mother would be. “I knew they were working so hard, but I never thought it would be something this big,” she said. Ms Helene Smuts, Director of Africa meets Africa, said: “You cannot learn until you start with what you know. This is the journey we took; now you must take your own.”
 

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