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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Max du Preez on South Africa’s leadership vacuum
2011-08-29

 

Present at the CR Swart Memorial Lecture was, from the left: Prof. Hussein Solomon, senior Professor in our Department of Political Science; Prof. Theo Neethling, Head of our Department of Political Science; Max du Preez and Prof. Lucius Botes,Dean of our Faculty of Humanities.
Photo: Stephen Collett

“Much has been going wrong in South Africa in the last few years and it’s all due to a lack of strong, visionary leadership. South Africans deserve better and should demand more integrity, courage and vision from the present political leadership,” veteran journalist and author Max du Preez told the audience at a packed Wynand Mouton Theatre at our university, on 25 August 2011.

Delivering this year’s CR Swart Memorial Lecture on the topic “Of Jacob, Julius, Jimmy and the Dancing Monkey”, Du Preez told the audience to look with much more critical eyes at the political leadership and decide who is doing the obvious, following his or her basest instincts or simply trying to play to the gallery. “Why look at a man like Julius Malema and let him upset us, why listen to Floyd Shivambu with his crude manners and let them define us?” Du Preez asked the more than 300 people attending the memorial lecture. The CR Swart Memorial Lecture, the 41st hosted by the UFS, attracted one of the largest crowds ever for a public lecture, with some people sitting on the steps inside the auditorium of the Wynand theatre.
 
Telling the story of African philospher Morena Mohlomi, who acted as a teacher to Basuto king Moshoeshoe, Du Preez told the audience that the country needs counter-intuitive leadership like the two leaders had demonstrated. Calling Mohlomi southern Africa’s first Pan Africanist, Du Preez said the extroadinary thing about Morena Mohlomi and his student was their gift of counter-intuitive leadership, leadership that was daring and visionary, leadership that did not simply do the obvious. Pointing out other visionary leaders like Nelson Mandela, Oliver Tambo, Walter Sisulu, Beyers Naude and Van Zyl Slabbert, Du Preez urged the audience to question “the quality of leadership of Cosatu, the Democratic Teachers Union that is messing up our education, the Communist Party, the Democratic Alliance, the Freedom Front Plus and Solidarity. If they don’t live up to our expectations, why do we still tolerate them?” Du Preez asked.
 
Du Preez also commended Prof. Jonathan Jansen, Vice Chancellor and Rector of the UFS, for his counter-intuitive leadership regarding the Reitz Residence incident and said Prof. Jansen’s solution, as controversial as it was, brought a much better outcome.
 
Please find attached the full speech of Max Du Preez.

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