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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Kovsie Extravaganza
2011-09-14

 

Once again, Kovsies will showcase its most talented students at the Sand du Plessis Theatre in the annual Kovsie Extravaganza on 21st and 22nd September 2011. With guest artists, Vusi ‘The Voice’ Mahlasela and Die Heuwels Fantasties, it promises to be a first-class production. Expect music styles as diverse as hip-hop and pantsula dancers, a student string quartet, jazz band, various vocal groups and the winners of the campus serenade competition.

While it will certainly be a night to remember, this year will also benefit a cause you will find hard to forget. R25 of every ticket sold will go towards the No Student Hungry campaign (NSH), currently feeding just over a hundred Kovsie students on a daily basis. This means that the donation from each ticket bought will effectively buy one student food for one day.

Hunger on the Kovsie campus is an invisible problem that few ever consider, yet it affects an estimated 10% of the 31 000 students at Kovsies. ‘The problem with hunger at a learning institution is that it hampers talent. A hungry person can never achieve their full potential,’ says Grace Jansen, patroness of NSH.

To help alleviate this situation, you can buy a ticket for R75 at the PACOFS ticket office and join us on the 21st or 22nd September at the Sand du Plessis Theatre. Not only will it be a great night out, but you'll be doing your bit to invest in talent. Watch the press over the next two weeks for more information on this initiative.

If you'd like to know more about this topic or to schedule an interview with Cornelia Faasen, please contact her on 051 401 2819 or e-mail faasenc@ufs.ac.za.

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