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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Lecture on interpretations and translations of San place names
2011-09-23

Prof. Peter Raper, recently appointed as Honorary Professor: Linguistics, in the Department of Language Management and Language Practice at the University of the Free State, will deliver his inaugural lecture on Tuesday evening, 27 September 2011. His topic for the evening is “Interpretations and translations of Bushman (San) place names”. With this inaugural lecture, he also introduces an interesting one-day international colloquium on the theme: “Name-change planning – striving towards authenticity”.A panel discussion about street-name changes in Bloemfontein forms part of this colloquium and promises to elicit a stimulating debate.

Prof. Raper is probably better known for three popular place-name dictionaries, Streekname in Suid-Afrika en Suidwes, published in 1972; the Dictionary of Southern African Place Names, published in 1987, updated in 1989 and published in 2004 with some additions as New dictionary of South African place names; and Hottentot (Khoekhoen) place names, a dictionary compiled in collaboration with the famous Prof. G S  Nienaber (a former Kovsie). In fact, Prof. Raper’s work is a continuation of their world-renowned series, Toponymica Hottentotica, which was published between 1977 and 1981. It is generally regarded as the most authoritative work on Hottentot place names. His current interest in Bushman place names builds on this pioneering work and is actually also a re-evaluation of the underestimated role of the Bushman with regard to place naming in South Africa up to now. His work offers a new perspective on what could be regarded as the “first” or earliest names of places in South Africa and brings a sobering perspective to the current debates regarding place-name changes where various claims are made about “who has given the name first”.

However, Prof. Raper is also known for his role in the standardisation of place names, both nationally and internationally. In South Africa, he has served on the South African National Place Names Committee (1972-1999), the South African Geographical Names Council (1999-2002) and, since 1981, on the Names Society of Southern Africa. Currently, he is an honorary member of this association. Since 1984, he has also been serving on the United Nations Group Experts on Geographical Names and has even been the Chairperson of this Leading international standardisation body (1991-2002).

Apart from this, Prof. Raper regularly publishes his research on geographical names in a variety of academic journals and still participates in the most important national and international conferences on names on a regular basis. Prof. Raper is honoured as South Africa’s foremost names expert.

His inaugural lecture will introduce a colloquium on names planning, presented by his host department. Experts from Lesotho, Zimbabwe and the USA are participating in the proceedings, amongst others, the current Chairperson of the Names Society of Southern Africa, Prof. Adrian Koopman (University of KwaZulu-Natal).

RSVP: Joy Maasdorp on +27(0)51 401 2405 or maasdorpjh@ufs.ac.za before or on Thursday, 22 September 2011.

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