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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

UFS Odeion School of Music (OSM) launched
2011-09-15

The University of the Free State’s (UFS) Odeion School of Music will be launched at the first Dean’s Concert in the Odeion on the Bloemfontein Campus on Friday, 16 September 2011.

The former Department of Music, in the Faculty of Humanities, has been transformed and will henceforth be known as the Odeion School of Music (OSM). This follows in the path of the corporate transition currently taking place at the university, which aims to reflect the progressive and dynamic striving towards excellence, as endorsed by the UFS Vice-Chancellor and Rector, Prof. Jonathan Jansen, and his management group.
 
Two years ago the faculty formulated a new mission with the aim to become an international faculty of excellence. An important component of it has been to create a pro-active marketing strategy and policy towards internationalisation and curriculum development.
 
The name Odeion School of Music portrays not only an excellent asset in the Free State, but also nationally and internationally. The school’s new name bears the respected Odeion brand and a number of successful and respected ensembles operate under this brand. These include the acclaimed residential Odeion String Quartet, as well as the Music Department’s student ensembles, the Junior Odeion String Quartet, the Odeion Sinfonia, and the Odeion Choir.
 
According to Prof. Nicol Viljoen, the Chairperson of the OSM, the name change was motivated by the following objectives:
  • The idea of a school within the Faculty of Humanities not only reflects an academic profile that does justice to the intention of the Department to reposition itself, but also simulates the current identity of the unit. This encompasses diverse thematic entities not only from an academic perspective, but also from a community and cultural perspective. The unit does this through providing services, which include arts entertainment, the provision of facilities, as well as a strong emphasis on community development.
  • With regard to an international perspective, it provides attractive possibilities not only from the perspective of a marketing and publicity profile, but also with regard to the identity of the unit.  
  • Hypothetically the new name allows more flexibility to complement the profile with reference to newly anticipated developments. These include the application of prestigious international experts as artistic fellows, membership to progressive European, jointly developed degree programmes and curriculum development initiatives, the founding of a chair in Orchestra Conducting, a master’s degree in Arts Management, as well as the incorporation of bio-kinetics in the teaching methodologies of performance practice, to name but a few.
  • From a management perspective it could also consolidate the perspective of scarce skill specialisation.
  • To give momentum to the establishment of the OSM, Mr Marius Coetzee was appointed as Innovation Manager. He is a former Project Manager of the European Degree in International Music Management – a joint degree initiative between three Universities from Norway, the Netherlands and Finland, funded by the EU in Brussels. His aim will be to develop and investigate aspects such as internationalisation, marketing, pro-active recruitment strategies, curriculum development and innovative teaching methodologies.
Mr Coetzee said music conservatories, from both European and American perspectives are managed and maintained as highly successful and substantial brands. From the European perspective some examples include the Sibelius Academy in Helsinki (Finland), the Liszt Academy in Budapest (Hungary), the Grieg Academy in Bergen (Norway) and the former Sweelinck Academy in Amsterdam (Netherlands). Similar to the South African milieu, the majority of music conservatories in the USA and Canada are resident within an academic university.
However, unlike the South African reality, the majority of these institutions have a value-added identity portrayed by a specific name. Such an example is the renowned Peabody Conservatory of the University of Baltimore or the Jacobs School of Music at the Indiana University Bloomington, to name but a few.
 
The Dean’s Concert will highlight performances of students in the school. The concert will probably become a regular event in future Spring Music Festivals.


Media Release
15 September 2011
Issued by: Lacea Loader
Director: Strategic Communication
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: news@ufs.ac.za
 

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