Latest News Archive

Please select Category, Year, and then Month to display items

PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

UFS a much safer place

2011-09-20

First-year students Chuma Nyiko (left) and Mabasa Teleni next to one of the red poles installed on our Bloemfontein Campus.
Photo: Amanda Tongha

Students and staff at our Bloemfontein Campus can feel even safer, with several initiatives being put in place to ensure their safety.

The stop-and-search actions of the recent past, which are being carried out at all the main gates of our Bloemfontein Campus, seem to be successful, since car theft has decreased on the campus. Mr Willie Frankim, Head of Protection Services, says the stop-and-search actions are carried out sporadically, but have a definite effect on crime at the campus. Mr Frankim says only one vehicle has been stolen in the past two months as opposed to the many more that have been stolen in the past.

The message that safety is viewed in a serious light reaches as far as our university’s parking areas and walkways, which are being patrolled by security staff. Mr Frankim says a security officer is placed in all the large parking areas, while other personnel are distributed across the entire campus, especially at key areas, such as at the library and student centre.

Our university also recently installed more than 30 red poles across the entire campus. Each of these red poles is fitted with a panic button by means of which help can be summoned. Should a student or staff member feel unsafe, all they have to do is press the button and cameras, which are installed in the vicinity, will focus on the pole and Protection Services will send assistance. Twenty five of these poles are already working and ten more still have to be activated.

Students and staff can also phone Protection Services on 051 401 2911 if they feel uncomfortable about their safety. They can use this number, for example, to ask a security officer to accompany them to their car.

Back

Economic and Management Sciences

Education

Health Sciences

The Humanities

Law

Natural and Agricultural Sciences

Theology and Religion

Open Distance Learning

Business School

We use cookies to make interactions with our websites and services easy and meaningful. To better understand how they are used, read more about the UFS cookie policy. By continuing to use this site you are giving us your consent to do this.

Accept