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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Shuttle services for senior medical students
2011-09-26

 

Senior medical students who make use of the shuttle services are standing next to the mini-bus.

On Friday, 30 September 2011, our university will officially launch its shuttle service for medical students. This function will take place from 12:00 to 13:00 at the Faculty of Health Sciences’ CJC Nel Reception Venue in the Francois Retief Building on our Bloemfontein Campus.

Two years ago. Dr Scarpa Schoeman began working at Internal Medicine at our Faculty of Health Sciences. Early on, he identified the transport problems of fourth- and fifth-year medical students (Phase-3 students) in the English class.
 
There are 65 Phase-3 students in the English class who are currently struggling with transport and who are part of this project. About 90% of them are bursary students at the university who, according to Schoeman, are consequently also struggling with finances. These students used public transport like taxis to move between hospital rounds and classes in the past. On average, it would cost them up to R4 000 per year for these daily travels between the UFS and the various training hospitals.
 
By the end of March 2011, NetCare had donated two mini-busses to the UFS and since 11 April, the shuttle services were available to medical students. Prof. Gert van Zyl (Dean of our Faculty of Health Sciences), Mr Mickey Gordon (Head: Marketing, Institutional Advancement and Sport) and the Rector, Prof. Jonathan Jansen, negotiated with NetCare. Gordon was also responsible for the branding of the busses. PPS and Pfizer are both sponsors who contributed to this.
 
This project is managed by Dr Schoeman, assisted by Mrs Anne-Marie Nel, who handles the administration as the Phase-3 secretary.
 
“It is important for us from the project management that students won’t see this as another taxi, but as a shuttle service of the university. Any senior medical student may make use of it, but it is mainly the under-privileged student from the English class who makes use of it.”
 
The two Quantum mini-busses do the circuit according to fixed schedules each day.  The route starts at the Francois Retief Building on our Bloemfontein Campus and then travels to the National Hospital, the Free State Psychiatric Complex (Oranje), Pelonomi, 3 Military Hospital (at Tempe) and then back again to Universitas Hospital.

 

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