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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Public Tourism lecture at Qwaqwa Campus a first
2011-10-03

 

Attending the Tourism Month celebrations were from the left: Dr Elias Malete, Qwaqwa Campus Principal; Minister Marthinus van Schalkwyk; and Dr Choice Makhetha, Vice-Rector: External Relations (actg).
Photo: Thabo Kessah

Tourism Month was celebrated in style at our Qwaqwa Campus with the hosting of the first ever Public Tourism Lecture. The lecture was part of the national Tourism Month celebrations and was organised by the National Department of Tourism in partnership with the UFS, the Central University of Technology, Free State and the University of Johannesburg (UJ).

The keynote address was presented by UJ’s Ms Milena Ivanovic, whose paper was entitled Cultural Tourism – Global and Local Perspective. This presentation was followed by a discussion by a panel of experts, namely Prof. Doreen Atkinson, Ms Merle Naidoo (both from the UFS), Prof. Albert Strydom (CUT), Dr Webber Ndoro (African World Heritage Fund), Ms Leonore Beukes (Department of Tourism) and Dr Kevin Mearns (UJ).

In acknowledgement of the role that institutions of higher learning play in advancing the tourism agenda, Minister of Environmental Affairs & Tourism, Marthinus van Schalkwyk, said that South Africa was now in a better position to welcome tourists compared to pre-1994.

“Before 1994 we had less than 500 000 foreign arrivals in the country while in 2010 we had over 10 million of whom 8 million were tourists. In 2006 only 26 airlines were using our airports, but now there are over 50 airlines,” he said.

Also in attendance were Free State MEC for Economic Development, Tourism and Environmental Affairs, Mxolisi Dukwana, and the UFS team led by Qwaqwa Campus Principal, Dr Elias Malete, and Vice-Rector: External Relations, Dr Choice Makhetha.

The Tourism Month festivities were concluded by a tough, but informative Poster Presentation Competition that pitted UFS, UJ and CUT students against each other.

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