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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Cultivating excellence and success through academics
2011-10-07

 

Unlocking potential. At the Golden Key South African Summit 2011 were, from the left: Dr Derek Swemmer, Registrar (UFS); Prof. Driekie Hay, Vice-Rector: Academic; Mr Ryk Neethling and Ms Charlene Gunter, Director: Golden Key International Honour Society, South Africa.
Photo: Phelekwa Mpono

More than 130 delegates are gathering for the Golden Key, South African Summit at the Bloemfontein Campus of the University of the Free State (UFS). Golden Key International Honour Society recognises academic excellence and uses knowledge to transform lives. It has 400 chapters in eight countries. Of South Africa’s 12 chapters, 11 were present at the summit.

Prof. Driekie Hay, Vice-Rector: Academic at the UFS, welcomed delegates from the respective chapters. She commended them for their perseverance and dedication to excel. “Your academic aspirations and commitment contribute to cultivating a culture of excellence. It will provide a better future for every South African citizen,” she said. Prof. Hay challenged delegates also to “act” by turning their knowledge into actions to advance not only themselves but also society. She also urged them to “discover” everything about themselves, their chosen disciplines, allies and oppositions. “Mostly, you must internalise the spirit of lifelong learning,” she said.

Mr Ryk Neethling, Olympic gold medallist and businessman, was the first keynote speaker. He took everyone through the steps that ultimately led to the moment of victory for him and his team. “We found a way to compete with heart and determination in the 2004 Olympic Games. We were prepared and we took everyone by surprise. “To achieve what one has set one’s mind to, we must dream big,” he said. “Play your part in the team and be confident. Remember that you are victors and not victims,” he urged. He further emphasised the importance of making one’s own luck and, most of all, never to give up.

Another speaker for the summit includes Ms Peggy-Sue Khumalo, former Miss South Africa. Dr Derek Swemmer, Registrar (UFS) will present a workshop on Strategic Action Planning.

This event is the first external lecture that is presented in the Metro’s found in the new Health Sciences Building on the Bloemfontein Campus of the UFS.
 

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