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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Nothing beats hard work, says Kovsie
2011-10-13

 

Khethiwe Mtshali

Khethiwe Mtshali is a classic example of a go-getter. This hard-working 23-year-old student from Ladysmith, who is currently studying at our Qwaqwa Campus, strongly believes in her own abilities. She believes that hard work pays off and that a person will be richly rewarded if you give it your best. Khethiwe has recently returned from a month-long visit to China where she was stationed at the Fresh Water Fisheries Research Centre of the Chinese Academy of Fishery Sciences in Wuxi City.

“I was nominated to go to China to learn and conduct research, as South Africa lacks expertise in the field of food security and related fields of science,” says Khethiwe, a 2011 recipient of the Golden Key Award and an M.Sc.in Zoology student who specialises in Parasitology.
 
“The Chinese is a hard-working nation that I wish we could emulate as South Africans. Doing my research on parasitology of fish and other related agricultural diseases over there was a worthwhile experience that will not only benefit me as an individual, but the entire Parasitology Division of the Department of Zoology and Entomology at the Qwaqwa Campus. This research is surely going to put the university and the entire country in a better position to compete with the best in the field of parasitology,” Khethiwe said.
 
After completing her B.Sc. degree in 2008, Khethiwe worked as a teacher at Ezakheni High School for a year before she was summoned back to our university by her mentor and Head of the Department of Zoology and Entomology, Dr Oriel Thekisoe, where she studied towards an honours degree, which she passed with distinction last year.
 
“If it had not been for Dr Thekisoe, I think I would still be a teacher whose potential would not have been tapped to the maximum. I wish to thank him for pushing me to do my best at all times. He has taught me that where there’s a will, there’s a way,” Khethiwe said.
 
The best is yet to come for this proud Kovsie who can teach you a thing or two in Chinese!

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