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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

ANC Centenary Dialogue reflects on past leadership
2011-10-12

 

Making their mark at the ANC Centenary Dialogue were, from left to right: Prof. Kwandiwe Kondlo, Senior Professor: Centre for Africa Studies (UFS); Dr Adekeye Adebajo, Director: Centre for Conflict Resolution (Cape Town); and Prof.  E C Ejiogu, Senior Researcher: Centre for Africa Studies (UFS). 

The Centre for Africa Studies at our university recently hosted its ANC Centenary Dialogue at the Bloemfontein Campus. Keynote speaker, Dr Adekeye Adebajo, delivered a paper titled Nelson Mandela, Thabo Mbeki, and the ANC’s Footprint in Africa. The lecture focused on two of South Africa’s democratically-elected presidents.

Mr Nelson Mandela was South Africa’s first democratically-elected president. This Nobel Peace Laureate played a prophetic leadership role in Africa in 1993. He was inspired by Mr Mahatma Gandhi’s tactics of ‘passive resistance’, which played a role in the ANC’s Defiance Campaign.
 
Mr Mandela’s visit to other African countries gave him insights into continental diplomacy and the tactics of other liberation movements. “The ANC used Madiba to embody the face of the struggle. He emerged from prison without any bitterness towards his enemies. He tirelessly promoted national reconciliation,” said Dr Adebajo.
 
Unlike other post-independence ‘Founding Fathers’, Mr Mandela bowed out gracefully at the end of his first presidential term in 1999, setting a standard for future African leaders aspiring to greatness. “Mr Mandela’s lasting legacies are his efforts at promoting national and international peacemaking,” elaborated Dr Adebajo.
 
Mr Thabo Mbeki challenged Africans to discover a sense of their own self-confidence after centuries of slavery and colonialism. Under his foreign policy, South Africa established solid credentials to become Africa’s leading power. He sought multilateral solutions to resolve regional conflicts. Mr Mbeki also sent peacekeepers abroad and increased South Africa’s credibility as a major geostrategic player in Africa.
 
Many question whether Mr Mbeki’s heirs, President Jacob Zuma and beyond, will maintain the same level of commitment to the continent that he demonstrated. Mr Mbeki has bequeathed this foreign policy legacy to his successors. “These very different ANC leaders have left a heavy African footprint on the sands of time,” concluded Dr Adebajo.

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