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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Thakaneng bridge: Valentines Promotions
2009-02-13

Thakaneng bridge: Valentines Promotions

Thakaneng bridge: Valentines Promotions - 13 February. Special discount! Prizes to be won!

  1. TRÄUMEREI

Enige twee ontbyte kry `n glasie sap en koffie gratis.
Enige middagete kry `n trammazini of glas huiswyn gratis.

Any two breakfasts get a free juice and coffee.
A free glass of wine or a trammazini with any lunch.

  1. VARSITY INFORMATION & TECHNOLOGY

Spend R1000.00 or more and stand a chance to win an Ipod Shuffle.
More specials in store.

Spandeer R1000.00 of meer en staan `n kans om `n Ipod Shuffle te wen.
Daar sal ook ander spesiale aanbiedinge in die winkel wees.

  1. VETKOEK FACTORY

Heart shaped vetkoek with delicious fillings and get a free heart shaped chocolate with every vetkoek.

Kom geniet `n hartvormige vetkoek met `n smaaklike vulsel en kry `n gratis hartvormige sjokolade.

  1. VARSITY HAIR STUDIO

Make Friday the 13th your lucky day at VARSITY HAIR STUDIO.
Amazing discounts will be given away!

Maak Vrydag die 13de jou gelukkige dag by VARSITY HAIR STUDIO.
Groot afslag op byna alles.

  1. KOVSIE PRIVAAT AKKOMMODASIE

Alle bestaande klante kom neem deel aan `n gelukstrekking en staan `n kans om `n etebewys ter waarde van R400.00 te wen.

All existing clients can enter into a lucky draw and stand a chance to win a free meal worth R400.00.

  1. XEROX

Kom neem deel aan `n “lucky draw” en wen een van verskeie geskenke.
Enter the lucky draw and win one of many prizes.

  1. MELLIN

LEVI, POLO en LUXION-KUKA promosies. Gratis geskenke wannneer `n raam gekoop word.
LEVI, POLO and LUXION-KUKA promotions. A free gift with any frame bought.

8. FRIENDLY SEVEN ELEVEN
Lots of in-store give-aways.
Vele weggee geskenke in die winkel. Besoek ons gerus.

9. RUSH HOUR
Kom prik `n ballon en wen een van vele pryse, waaronder T-hemde, `n koek, teddiebeer of dalk ‘n mini- make over.
Ons maak ook `n plan vir lekker musiek op die brug!

Win a cake, T-shirt ,a teddy bear or a mini make over in our burst a balloon competition.

10.MAMA`S KITCHEN
Kom neem deel aan `n gelukstrekking en wen `n piekniekmandjie vir twee.
`n Gratis geskenkie vir die eerste 100 klante.

Enter the lucky draw and stand a chance to win a picnic hamper for two.
The first 100 clients will receive a gift.

11. ROASTERS
Kom koop een chip twister en kry een gratis.
Buy ` chip twister and get one for free.

12 DIE DELI

Koop een groot ontbyt en kry `n damesontbyt gratis.
Kry skyfies gratis saam met enige burger.

Buy a breakfast and get a ladies breakfast free.
Free chips with any burger.

  1. NASHUA MOBILE

Buy airtime for R10.00 or more and stand a chance to win airtime worth R55.00
Koop lugtyd van R10.00 of meer en staan `n kans om lugtyd ter waarde van R55.00 te wen.

  1. VAN SCHAIK BOEKHANDEL

Alle aankope op 13 Februarie kwalifiseer vir `n gelukstrekking op die 14de Februarie en staan `n kans om `n geskenk te wen waaronder wetenskaplike sakrekenaars, memory sticks en penstelle.

All clients who buy something on 13 February 2009 may enter a lucky draw and may win gifts like pen sets, scientific calculator or a memory stick on 14 February 2009.

  1. ROCKSTARS

Kom koop `n T-hemp en staan `n kans om `n geskenk te wen.

Buy a T-shirt and stand a chance to win a prize

 

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