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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Colloquium focuses on protection of reproductive and sexual health in Africa
2011-10-28

 
Proff. Charles Ngwena and Loot Pretorius, both from the Department of Constitutional Law and Philosophy of Law at the UFS.
Photo: Stephen Collett

Our Department of Constitutional Law and Philosophy of Law of the Faculty of Law recently convened a two-day colloquium with the theme, ‘Strengthening protection of reproductive and sexual health in Africa through human rights’.

The colloquium built upon the work of the university’s LLM Programme in Reproductive and Sexual Rights, which trains law graduates to become specialists in reproductive and sexual health as human rights. The LLM Programme was first established in 2005. The colloquium brought together delegates from different professional backgrounds, including academia, health sciences and human-rights advocates from across the African region as well as from abroad.
 
Delegates addressed the theme of the colloquium in sessions  organised around the topics: HIV/Aids and human rights; sexual health and sexual rights; reproductive health and rights; abortion-related issues; and the intersection between cultural and religious perspectives and sexual and reproductive health and rights.
 
According to Prof. Charles Ngwena, Director of the LLM Programme, and co-convener of the colloquium together with Dr Ebenezer Durojaye, Postdoctoral Fellow in the Department of Constitutional Law at the UFS, the discussions flowing from the papers were to:
  • identify a persistent gap or challenge in the respect, protection and realisation of reproductive and/or sexual health as a human right under African human rights systems; and
  • advance arguments and suggestions that are aimed at addressing the gap or challenge and ultimately strengthening African human rights systems.
To address the regional dimension of the colloquium, the papers  delivered ultimately addressed selected reproductive and/or sexual health or right issues from a regional rather than a mere country perspective so that the experiences and challenges of the African region are captured.

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