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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

School of Open Learning opens access to education
2011-12-08

 

Lanterns filled the night sky as UFS staff and guests celebrate the launch of the School of Open Learning at the university’s South Campus.
Photo: Johan Pretorius

A school which intends to expand the boundaries of the University of the Free State (UFS), providing good quality higher education that is based on open learning principles. That is what the School of Open Learning at the UFS’ South Campus is all about. The School was officially launched at the Campus on 28 November 2011. 

Prof. Daniella Coetzee, Dean of the School, told guests at the launch that the School will provide opportunities other than traditional learning in higher education and open up access to those who have not had the opportunity to study at a higher education institution. This includes taking programmes and courses to students at off-campus sites. The School of Open Learning currently has 46 off-campus sites across most of the provinces, i.e. Mpumalanga, KwaZulu-Natal, North West, Eastern Cape, Northern Cape, Limpopo and the Free State. The off-campus sites are serviced by a total of 350 university lecturers and well-trained facilitators and tutors.
 
At the moment most of the programmes and courses managed by the School of Open Learning have their academic home in the Faculty of Education, providing upgrading of the qualifications of teachers as well as in-service training. In 2011 the School of Open Learning enrolled more than 4000 students for the Education courses. To date a total of 28 000 teachers have been enrolled at the School to upgrade their teaching qualifications.
 
Collaboration with the Faculty of Law in the presentation of a BIuris degree on off-campus sites is also on the calendar for 2012. This degree will be offered through contact and E-learning at three off-campus sites: Johannesburg, Durban and Cape Town.
 
The University Preparation Programme (UPP) will also form part of the School of Open Learning. This programme has proven to be extremely successful in providing students access to undergraduate degrees at the UFS. The curriculum for this bridging year offers courses from the Faculties of Economic and Management Sciences, Human and Social Sciences as well as Natural and Agricultural Sciences. Since 1993 more than 4500 students have enrolled for degree purposes after successfully completing the UPP: 1641 degrees have been awarded to students who began their studies in the programme (including 168 honours degrees; 25 master’s and 8 M.B.Ch.B. degrees). The existing foundation course in the UPP is being adapted to also serve NQF level 4 in further education. As far back as 1998, the Sunday Times (Best in Education, 1998:1) named this programme as “one of the most innovative education programmes” in a special supplement on higher education in South Africa.
 
Also speaking at the event, Prof. Jonathan Jansen, Vice-Chancellor and Rector, said the South Campus is to become intellectually alive with possibilities. He said the university will make sure there are seminars, conferences and classes where students can mingle across the university’s three campuses.

 

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